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Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.
Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, Suzuki T, Koda Y, Chu PS, Taniki N, Yamaguchi A, Kanamori M, Kamada N, Hattori M, Ashida H, Sakamoto M, Atarashi K, Narushima S, Yoshimura A, Honda K, Sato T, Kanai T. Nakamoto N, et al. Nat Microbiol. 2019 Mar;4(3):492-503. doi: 10.1038/s41564-018-0333-1. Epub 2019 Jan 14. Nat Microbiol. 2019. PMID: 30643240
MyD88-dependent pathway accelerates the liver damage of Concanavalin A-induced hepatitis.
Ojiro K, Ebinuma H, Nakamoto N, Wakabayashi K, Mikami Y, Ono Y, Po-Sung C, Usui S, Umeda R, Takaishi H, Yamagishi Y, Saito H, Kanai T, Hibi T. Ojiro K, et al. Biochem Biophys Res Commun. 2010 Sep 3;399(4):744-9. doi: 10.1016/j.bbrc.2010.08.012. Epub 2010 Aug 7. Biochem Biophys Res Commun. 2010. PMID: 20696131
Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation.
Mikami Y, Mizuno S, Nakamoto N, Hayashi A, Sujino T, Sato T, Kamada N, Matsuoka K, Hisamatsu T, Ebinuma H, Hibi T, Yoshimura A, Kanai T. Mikami Y, et al. PLoS One. 2014 Jan 2;9(1):e84619. doi: 10.1371/journal.pone.0084619. eCollection 2014. PLoS One. 2014. PMID: 24392145 Free PMC article.
Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis.
Amiya T, Nakamoto N, Chu PS, Teratani T, Nakajima H, Fukuchi Y, Taniki N, Yamaguchi A, Shiba S, Miyake R, Katayama T, Ebinuma H, Kanai T. Amiya T, et al. Sci Rep. 2016 Oct 11;6:35146. doi: 10.1038/srep35146. Sci Rep. 2016. PMID: 27725760 Free PMC article.
Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling.
Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Hida S, Okada Y, Kurihara C, Ebinuma H, Nakamoto N, Saito H, Hibi T, Miura S, Hokari R, Kanai T. Teratani T, et al. J Hepatol. 2017 Oct;67(4):780-790. doi: 10.1016/j.jhep.2017.05.020. Epub 2017 May 26. J Hepatol. 2017. PMID: 28554874
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