Nakamura Y - Search Results

1

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.

Traxler EA, Yao Y, Wang YD, Woodard KJ, Kurita R, Nakamura Y, Hughes JR, Hardison RC, Blobel GA, Li C, Weiss MJ. Traxler EA, et al. Among authors: nakamura y. Nat Med. 2016 Sep;22(9):987-90. doi: 10.1038/nm.4170. Epub 2016 Aug 15. Nat Med. 2016. PMID: 27525524 Free PMC article.

2

High level of fetal-globin reactivation by designed transcriptional activator-like effector.

Zhan J, Irudayam MJ, Nakamura Y, Kurita R, Nienhuis AW. Zhan J, et al. Among authors: nakamura y. Blood Adv. 2020 Feb 25;4(4):687-695. doi: 10.1182/bloodadvances.2019000482. Blood Adv. 2020. PMID: 32084259 Free PMC article.

3

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.

Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE. Canver MC, et al. Among authors: nakamura y. Nature. 2015 Nov 12;527(7577):192-7. doi: 10.1038/nature15521. Epub 2015 Sep 16. Nature. 2015. PMID: 26375006 Free PMC article.

4

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.

Huang P, Keller CA, Giardine B, Grevet JD, Davies JOJ, Hughes JR, Kurita R, Nakamura Y, Hardison RC, Blobel GA. Huang P, et al. Among authors: nakamura y. Genes Dev. 2017 Aug 15;31(16):1704-1713. doi: 10.1101/gad.303461.117. Epub 2017 Sep 15. Genes Dev. 2017. PMID: 28916711 Free PMC article.

5

Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies.

Loucari CC, Patsali P, van Dijk TB, Stephanou C, Papasavva P, Zanti M, Kurita R, Nakamura Y, Christou S, Sitarou M, Philipsen S, Lederer CW, Kleanthous M. Loucari CC, et al. Among authors: nakamura y. Hum Gene Ther Methods. 2018 Feb;29(1):60-74. doi: 10.1089/hgtb.2017.190. Hum Gene Ther Methods. 2018. PMID: 29325430 Free PMC article.

6

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding.

Martyn GE, Wienert B, Yang L, Shah M, Norton LJ, Burdach J, Kurita R, Nakamura Y, Pearson RCM, Funnell APW, Quinlan KGR, Crossley M. Martyn GE, et al. Among authors: nakamura y. Nat Genet. 2018 Apr;50(4):498-503. doi: 10.1038/s41588-018-0085-0. Epub 2018 Apr 2. Nat Genet. 2018. PMID: 29610478

7

A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site.

Martyn GE, Wienert B, Kurita R, Nakamura Y, Quinlan KGR, Crossley M. Martyn GE, et al. Among authors: nakamura y. Blood. 2019 Feb 21;133(8):852-856. doi: 10.1182/blood-2018-07-863951. Epub 2019 Jan 7. Blood. 2019. PMID: 30617196 Free article.

8

CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells.

Chung JE, Magis W, Vu J, Heo SJ, Wartiovaara K, Walters MC, Kurita R, Nakamura Y, Boffelli D, Martin DIK, Corn JE, DeWitt MA. Chung JE, et al. Among authors: nakamura y. PLoS One. 2019 Jan 15;14(1):e0208237. doi: 10.1371/journal.pone.0208237. eCollection 2019. PLoS One. 2019. PMID: 30645582 Free PMC article.

9

Human erythroblasts with c-Kit activating mutations have reduced cell culture costs and remain capable of terminal maturation.

Couch T, Murphy Z, Getman M, Kurita R, Nakamura Y, Steiner LA. Couch T, et al. Among authors: nakamura y. Exp Hematol. 2019 Jun;74:19-24.e4. doi: 10.1016/j.exphem.2019.04.001. Epub 2019 Apr 18. Exp Hematol. 2019. PMID: 31004744 Free article.

10

Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies.

Wang L, Li L, Ma Y, Hu H, Li Q, Yang Y, Liu W, Yin S, Li W, Fu B, Kurita R, Nakamura Y, Liu M, Lai Y, Li D. Wang L, et al. Among authors: nakamura y. Cell Res. 2020 Mar;30(3):276-278. doi: 10.1038/s41422-019-0267-z. Epub 2020 Jan 7. Cell Res. 2020. PMID: 31911671 Free PMC article. No abstract available.

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