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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P. Nakao A, et al. Nature. 1997 Oct 9;389(6651):631-5. doi: 10.1038/39369. Nature. 1997. PMID: 9335507
TGF-beta rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGF-beta responses....
TGF-beta rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGF-b …
Lack of responsiveness to TGF-beta1 in a thyroid carcinoma cell line with functional type I and type II TGF-beta receptors and Smad proteins, suggests a novel mechanism for TGF-beta insensitivity in carcinoma cells.
Heldin NE, Bergström D, Hermansson A, Bergenstråhle A, Nakao A, Westermark B, ten Dijke P. Heldin NE, et al. Mol Cell Endocrinol. 1999 Jul 20;153(1-2):79-90. doi: 10.1016/s0303-7207(99)00086-6. Mol Cell Endocrinol. 1999. PMID: 10459856
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine. In the present study we have investigated the expression of TGF-beta receptors (TbetaR's) and SMAD proteins in non-neoplastic and neoplastic thyroid follicle cells. ...In summary, our data shows abun …
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine. In the present study we have investigated the expression of …
Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells.
Ishisaki A, Yamato K, Hashimoto S, Nakao A, Tamaki K, Nonaka K, ten Dijke P, Sugino H, Nishihara T. Ishisaki A, et al. J Biol Chem. 1999 May 7;274(19):13637-42. doi: 10.1074/jbc.274.19.13637. J Biol Chem. 1999. PMID: 10224135
We previously reported that Smad7 is an activin A-inducible antagonist of activin A-induced growth arrest and apoptosis in HS-72 cells. Interestingly, although mRNA expression of Smad6 was induced by activin A in HS-72 cells, Smad6 showed no antagonistic effe …
We previously reported that Smad7 is an activin A-inducible antagonist of activin A-induced growth arrest and apoptosis in HS- …
Intracellular signaling of osteogenic protein-1 through Smad5 activation.
Tamaki K, Souchelnytskyi S, Itoh S, Nakao A, Sampath K, Heldin CH, ten Dijke P. Tamaki K, et al. J Cell Physiol. 1998 Nov;177(2):355-63. doi: 10.1002/(SICI)1097-4652(199811)177:2<355::AID-JCP17>3.0.CO;2-8. J Cell Physiol. 1998. PMID: 9766532
A Smad5-2SA mutant, in which the two most carboxy-terminal serine residues were mutated to alanine residues, was found to act as a dominant negative inhibitor of OP-1-induced responses upon its transfection into various cell types, including ROB-C26 cells, in contra
A Smad5-2SA mutant, in which the two most carboxy-terminal serine residues were mutated to alanine residues, was found to act as a
Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors.
Souchelnytskyi S, Nakayama T, Nakao A, Morén A, Heldin CH, Christian JL, ten Dijke P. Souchelnytskyi S, et al. J Biol Chem. 1998 Sep 25;273(39):25364-70. doi: 10.1074/jbc.273.39.25364. J Biol Chem. 1998. PMID: 9738003
A subclass of Smad proteins has recently been identified that antagonize, rather than transduce, TGF-beta family signals. Smad7, for example, binds to and inhibits signaling downstream of TGF-beta receptors. ...However, XSmad7 is a less efficient inhibitor of TbetaR
A subclass of Smad proteins has recently been identified that antagonize, rather than transduce, TGF-beta family signals. Smad7, for
Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line.
Shimizu A, Kato M, Nakao A, Imamura T, ten Dijke P, Heldin CH, Kawabata M, Shimada S, Miyazono K. Shimizu A, et al. Genes Cells. 1998 Feb;3(2):125-34. doi: 10.1046/j.1365-2443.1998.00174.x. Genes Cells. 1998. PMID: 9605406
BACKGROUND: Activin A is a multifunctional protein, which is a member of the transforming growth factor-beta (TGF-beta) superfamily. ...RESULTS: We identified the receptors and Smad proteins activated by activin A in a human epidermal keratinocy …
BACKGROUND: Activin A is a multifunctional protein, which is a member of the transforming growth factor-beta (TGF-beta) …
Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway.
Nakao A, Röijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P. Nakao A, et al. J Biol Chem. 1997 Jan 31;272(5):2896-900. doi: 10.1074/jbc.272.5.2896. J Biol Chem. 1997. PMID: 9006934
Here we report the cloning of a Mad-related protein, termed Sma- and Mad-related protein 2 (Smad2). TGF-beta stimulated the phosphorylation and nuclear translocation of Smad2 in nontransfected Mv1Lu cells. ...Smad2 is closely linked to DPC4 on chromosome 18q21.1, a
Here we report the cloning of a Mad-related protein, termed Sma- and Mad-related protein 2 (Smad2). TGF-beta stimulated the phosphory …
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P. Nakao A, et al. EMBO J. 1997 Sep 1;16(17):5353-62. doi: 10.1093/emboj/16.17.5353. EMBO J. 1997. PMID: 9311995 Free PMC article.
Smad4 is distantly related to Smads 2 and 3, and forms a heteromeric complex with Smad2 after TGF-beta or activin stimulation. ...Smads 2, 3 and 4 accumulated in the nucleus upon TGF-beta1 treatment in Mv1Lu cells, and showed a synergistic effect in a transcr …
Smad4 is distantly related to Smads 2 and 3, and forms a heteromeric complex with Smad2 after TGF-beta or activin stimulation. ...Sma …
Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity.
Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, Iwamoto I. Nakao A, et al. J Exp Med. 2000 Jul 17;192(2):151-8. doi: 10.1084/jem.192.2.151. J Exp Med. 2000. PMID: 10899902 Free PMC article.
To address this issue, we developed transgenic mice expressing Smad7, an intracellular antagonist of TGF-beta/Smad signaling, selectively in mature T cells using a plasmid construct coding a promoter element (the distal lck promoter) that directs high expression in …
To address this issue, we developed transgenic mice expressing Smad7, an intracellular antagonist of TGF-beta/Smad signaling, selectively in …
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