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Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial.
Miki K, Maekura R, Nagaya N, Nakazato M, Kimura H, Murakami S, Ohnishi S, Hiraga T, Miki M, Kitada S, Yoshimura K, Tateishi Y, Arimura Y, Matsumoto N, Yoshikawa M, Yamahara K, Kangawa K. Miki K, et al. PLoS One. 2012;7(5):e35708. doi: 10.1371/journal.pone.0035708. Epub 2012 May 1. PLoS One. 2012. PMID: 22563468 Free PMC article. Clinical Trial.
In the ghrelin group, the mean change from pre-treatment in 6-MWD was improved at Week 3 (+40 m, within-group p = 0.033) and was maintained at Week 7 (+47 m, within-group p = 0.017), although the difference between ghrelin and placebo was not significant. ...
In the ghrelin group, the mean change from pre-treatment in 6-MWD was improved at Week 3 (+40 m, within-group p = 0.033) and was main …
Ghrelin administration for chronic respiratory failure: a randomized dose-comparison trial.
Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K. Matsumoto N, et al. Lung. 2015 Apr;193(2):239-47. doi: 10.1007/s00408-015-9685-y. Epub 2015 Jan 30. Lung. 2015. PMID: 25634352 Clinical Trial.
Change from baseline 6 MWD after treatment was similar between groups(1 μg/kg: 53.9 m, 2 μg/kg: 53.9 m, p = 0.99). Mean change in peak VO2 was significantly greater in the 2 μg/kg group (63.1 ml/min) than in the 1 μg/kg group (-63.8 ml/min, p = 0.048). ...
Change from baseline 6 MWD after treatment was similar between groups(1 μg/kg: 53.9 m, 2 μg/kg: 53.9 m, p = 0.99). Mean change …
Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa.
Tanaka M, Nakahara T, Muranaga T, Kojima S, Yasuhara D, Ueno H, Nakazato M, Inui A. Tanaka M, et al. Horm Behav. 2006 Aug;50(2):261-5. doi: 10.1016/j.yhbeh.2006.03.009. Epub 2006 Apr 27. Horm Behav. 2006. PMID: 16643914 Clinical Trial.
Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa.
Nakahara T, Kojima S, Tanaka M, Yasuhara D, Harada T, Sagiyama K, Muranaga T, Nagai N, Nakazato M, Nozoe S, Naruo T, Inui A. Nakahara T, et al. J Psychiatr Res. 2007 Nov;41(10):814-20. doi: 10.1016/j.jpsychires.2006.07.021. Epub 2006 Oct 19. J Psychiatr Res. 2007. PMID: 17054989
Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus.
Date Y, Shimbara T, Koda S, Toshinai K, Ida T, Murakami N, Miyazato M, Kokame K, Ishizuka Y, Ishida Y, Kageyama H, Shioda S, Kangawa K, Nakazato M. Date Y, et al. Cell Metab. 2006 Oct;4(4):323-31. doi: 10.1016/j.cmet.2006.09.004. Cell Metab. 2006. PMID: 17011505
Impact of Helicobacter pylori infection on gastric and plasma ghrelin dynamics in humans.
Isomoto H, Ueno H, Saenko VA, Mondal MS, Nishi Y, Kawano N, Ohnita K, Mizuta Y, Ohtsuru A, Yamashita S, Nakazato M, Kohno S. Isomoto H, et al. Am J Gastroenterol. 2005 Aug;100(8):1711-20. doi: 10.1111/j.1572-0241.2005.41492.x. Am J Gastroenterol. 2005. PMID: 16086706
Ghrelin and its therapeutic potential for cachectic patients.
Ashitani J, Matsumoto N, Nakazato M. Ashitani J, et al. Peptides. 2009 Oct;30(10):1951-6. doi: 10.1016/j.peptides.2009.07.002. Epub 2009 Jul 10. Peptides. 2009. PMID: 19595727 Review.
Ghrelin stimulates growth hormone secretion and food intake in aged rats.
Toshinai K, Mondal MS, Shimbara T, Yamaguchi H, Date Y, Kangawa K, Nakazato M. Toshinai K, et al. Mech Ageing Dev. 2007 Feb;128(2):182-6. doi: 10.1016/j.mad.2006.10.001. Epub 2006 Nov 15. Mech Ageing Dev. 2007. PMID: 17109935
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