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The shedding activity of ADAM17 is sequestered in lipid rafts.
Tellier E, Canault M, Rebsomen L, Bonardo B, Juhan-Vague I, Nalbone G, Peiretti F. Tellier E, et al. Among authors: nalbone g. Exp Cell Res. 2006 Dec 10;312(20):3969-80. doi: 10.1016/j.yexcr.2006.08.027. Epub 2006 Sep 5. Exp Cell Res. 2006. PMID: 17010968
Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.
Canault M, Leroyer AS, Peiretti F, Lesèche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G. Canault M, et al. Among authors: nalbone g. Am J Pathol. 2007 Nov;171(5):1713-23. doi: 10.2353/ajpath.2007.070021. Epub 2007 Sep 14. Am J Pathol. 2007. PMID: 17872973 Free PMC article.
HDLs activate ADAM17-dependent shedding.
Tellier E, Canault M, Poggi M, Bonardo B, Nicolay A, Alessi MC, Nalbone G, Peiretti F. Tellier E, et al. Among authors: nalbone g. J Cell Physiol. 2008 Mar;214(3):687-93. doi: 10.1002/jcp.21265. J Cell Physiol. 2008. PMID: 17786981
The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha receptors.
Canault M, Peiretti F, Kopp F, Bonardo B, Bonzi MF, Coudeyre JC, Alessi MC, Juhan-Vague I, Nalbone G. Canault M, et al. Among authors: nalbone g. Atherosclerosis. 2006 Jul;187(1):82-91. doi: 10.1016/j.atherosclerosis.2005.08.031. Epub 2005 Oct 7. Atherosclerosis. 2006. PMID: 16214147
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