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Current management of severe homozygous hypercholesterolaemias.
Naoumova RP, Thompson GR, Soutar AK. Naoumova RP, et al. Curr Opin Lipidol. 2004 Aug;15(4):413-22. doi: 10.1097/01.mol.0000137222.23784.2a. Curr Opin Lipidol. 2004. PMID: 15243214 Review.
Therapy insight: heart disease and the insulin-resistant patient.
Cook SA, Aitman T, Naoumova RP. Cook SA, et al. Among authors: naoumova rp. Nat Clin Pract Cardiovasc Med. 2005 May;2(5):252-60. doi: 10.1038/ncpcardio0194. Nat Clin Pract Cardiovasc Med. 2005. PMID: 16265509 Review.
MRI at 3 Tesla detects no evidence for ischemic brain damage in intensively treated patients with homozygous familial hypercholesterolemia.
Schmitz SA, O'Regan DP, Fitzpatrick J, Neuwirth C, Potter E, Tosi I, Hajnal JV, Naoumova RP. Schmitz SA, et al. Among authors: naoumova rp. Neuroradiology. 2007 Nov;49(11):927-31. doi: 10.1007/s00234-007-0273-6. Epub 2007 Jul 21. Neuroradiology. 2007. PMID: 17643240
Quantitative 3T MR imaging of the descending thoracic aorta: patients with familial hypercholesterolemia have an increased aortic plaque burden despite long-term lipid-lowering therapy.
Schmitz SA, O'Regan DP, Fitzpatrick J, Neuwirth C, Potter E, Tosi I, Hajnal JV, Naoumova RP. Schmitz SA, et al. Among authors: naoumova rp. J Vasc Interv Radiol. 2008 Oct;19(10):1403-8. doi: 10.1016/j.jvir.2008.06.020. Epub 2008 Aug 9. J Vasc Interv Radiol. 2008. PMID: 18693045 Clinical Trial.
Improved cardiovascular outcomes following temporal advances in lipid-lowering therapy in a genetically-characterised cohort of familial hypercholesterolaemia homozygotes.
Thompson GR, Seed M, Naoumova RP, Neuwirth C, Walji S, Aitman TJ, Scott J, Myant NB, Soutar AK. Thompson GR, et al. Among authors: naoumova rp. Atherosclerosis. 2015 Nov;243(1):328-33. doi: 10.1016/j.atherosclerosis.2015.09.029. Epub 2015 Sep 28. Atherosclerosis. 2015. PMID: 26433113 Free article.
Pioglitazone improves myocardial blood flow and glucose utilization in nondiabetic patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled study.
Naoumova RP, Kindler H, Leccisotti L, Mongillo M, Khan MT, Neuwirth C, Seed M, Holvoet P, Betteridge J, Camici PG. Naoumova RP, et al. J Am Coll Cardiol. 2007 Nov 20;50(21):2051-8. doi: 10.1016/j.jacc.2007.07.070. Epub 2007 Nov 5. J Am Coll Cardiol. 2007. PMID: 18021872 Free article. Clinical Trial.
Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content.
Thomas EL, Potter E, Tosi I, Fitzpatrick J, Hamilton G, Amber V, Hughes R, North C, Holvoet P, Seed M, Betteridge DJ, Bell JD, Naoumova RP. Thomas EL, et al. Among authors: naoumova rp. Atherosclerosis. 2007 Nov;195(1):e181-90. doi: 10.1016/j.atherosclerosis.2007.03.043. Epub 2007 May 7. Atherosclerosis. 2007. PMID: 17482623 Clinical Trial.
Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response.
Naoumova RP, Tosi I, Patel D, Neuwirth C, Horswell SD, Marais AD, van Heyningen C, Soutar AK. Naoumova RP, et al. Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2654-60. doi: 10.1161/01.ATV.0000190668.94752.ab. Epub 2005 Oct 13. Arterioscler Thromb Vasc Biol. 2005. PMID: 16224054
Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia.
Sun XM, Eden ER, Tosi I, Neuwirth CK, Wile D, Naoumova RP, Soutar AK. Sun XM, et al. Among authors: naoumova rp. Hum Mol Genet. 2005 May 1;14(9):1161-9. doi: 10.1093/hmg/ddi128. Epub 2005 Mar 16. Hum Mol Genet. 2005. PMID: 15772090
USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome.
Shoulders CC, Naoumova RP. Shoulders CC, et al. Among authors: naoumova rp. Trends Mol Med. 2004 Aug;10(8):362-5. doi: 10.1016/j.molmed.2004.06.011. Trends Mol Med. 2004. PMID: 15310455 Review.
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