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Naphthablins B and C, Meroterpenoids Identified from the Marine Sediment-Derived Streptomyces sp. CP26-58 Using HeLa Cell-Based Cytological Profiling.
Martucci H, Campit SE, Gee SR, Bray WM, Gokey T, Cada AK, Yen TY, Minoura K, Guliaev AB, Lokey RS, Amagata T. Martucci H, et al. J Nat Prod. 2017 Mar 24;80(3):684-691. doi: 10.1021/acs.jnatprod.6b00996. Epub 2017 Jan 27. J Nat Prod. 2017. PMID: 28128950
Furthermore, three naphthoquinone meroterpenoids, naphthablin A (2) and two new derivatives designated as naphthablins B (3) and C (4), were isolated from other cytotoxic fractions. ...
Furthermore, three naphthoquinone meroterpenoids, naphthablin A (2) and two new derivatives designated as naphthablins B (3) and C (4 …
Isolation from Streptomyces of a novel naphthoquinone compound, naphthablin, that inhibits Abl oncogene functions.
Umezawa K, Masuoka S, Ohse T, Naganawa H, Kondo S, Ikeda Y, Kinoshita N, Hamada M, Sawa T, Takeuchi T. Umezawa K, et al. J Antibiot (Tokyo). 1995 Jul;48(7):604-7. doi: 10.7164/antibiotics.48.604. J Antibiot (Tokyo). 1995. PMID: 7649855 Free article.
Mass and NMR spectroscopy including HMBC revealed that it had a novel naphthoquinone structure with a monoterpene, and we named it "naphthablin". Naphthablin inhibited Abl-induced morphological transformation in v-ablts-NIH3T3 cells at around 30 micrograms/ml, and s …
Mass and NMR spectroscopy including HMBC revealed that it had a novel naphthoquinone structure with a monoterpene, and we named it "napht …
Antimicrobial and Cytotoxic Naphthoquinones from Microbial Origin: An Updated Review.
Kashi ME, Ghorbani M, Badibostan H, Seidel V, Hosseini SH, Asili J, Shakeri A, Sahebkar A. Kashi ME, et al. Mini Rev Med Chem. 2024;24(8):844-862. doi: 10.2174/1389557523666230911141331. Mini Rev Med Chem. 2024. PMID: 37694782 Free article. Review.
During this period, potent cytotoxic NQs such as naphthablin B (46) and hygrocin C (30) against HeLa (IC(50)=0.23 mug/ml) and MDA-MB-431 (IC(50)=0.5 mug/ml) cell lines was reported, respectively. ...
During this period, potent cytotoxic NQs such as naphthablin B (46) and hygrocin C (30) against HeLa (IC(50)=0.23 mug/ml) and MDA-MB- …