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Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells by targeting beta-catenin-mediated transactivation and cell-cell adhesion pathways.
Narayan S. Narayan S. J Mol Histol. 2004 Mar;35(3):301-7. doi: 10.1023/b:hijo.0000032361.98815.bb. J Mol Histol. 2004. PMID: 15339049 Review.
Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells.
Ramisetti SR, Pandey MK, Lee SY, Karelia D, Narayan S, Amin S, Sharma AK. Ramisetti SR, et al. Among authors: narayan s. Eur J Med Chem. 2018 Jan 1;143:1919-1930. doi: 10.1016/j.ejmech.2017.11.006. Epub 2017 Nov 4. Eur J Med Chem. 2018. PMID: 29133035 Free PMC article.
Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics.
Law ME, Corsino PE, Narayan S, Law BK. Law ME, et al. Among authors: narayan s. Mol Pharmacol. 2015 Nov;88(5):846-52. doi: 10.1124/mol.115.099325. Epub 2015 May 27. Mol Pharmacol. 2015. PMID: 26018905 Free PMC article.
Favorable results with palbociclib and its recent U.S. Food and Drug Administration approval demonstrate that CDK inhibitors with narrow selectivity profiles can have clinical utility for therapy based on individual tumor genetics. ...
Favorable results with palbociclib and its recent U.S. Food and Drug Administration approval demonstrate that CDK inhibitors with nar …
A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.
Jaiswal AS, Banerjee S, Panda H, Bulkin CD, Izumi T, Sarkar FH, Ostrov DA, Narayan S. Jaiswal AS, et al. Among authors: narayan s. Mol Cancer Res. 2009 Dec;7(12):1973-83. doi: 10.1158/1541-7786.MCR-09-0309. Epub 2009 Dec 8. Mol Cancer Res. 2009. PMID: 19996303 Free PMC article.
Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation.
Nayak A, Das S, Nayak D, Sethy C, Narayan S, Kundu CN. Nayak A, et al. Among authors: narayan s. Cell Oncol (Dordr). 2019 Apr;42(2):157-171. doi: 10.1007/s13402-018-0417-1. Epub 2019 Jan 3. Cell Oncol (Dordr). 2019. PMID: 30603978
ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.
Narayan S, Ramisetti S, Jaiswal AS, Law BK, Singh-Pillay A, Singh P, Amin S, Sharma AK. Narayan S, et al. Eur J Med Chem. 2019 Jan 1;161:456-467. doi: 10.1016/j.ejmech.2018.10.052. Epub 2018 Oct 23. Eur J Med Chem. 2019. PMID: 30384048 Free PMC article.
It appears that the complex mechanism of cytotoxicity for 7b includes abrogation of 5-FU-induced the S phase, reduction of the phosphorylation of Chk1 at S317P, S345P and S296P, increased γH2AX staining, activation of caspase 3/PARP1 cleavage, and enhancement of Bax/Bcl2 r …
It appears that the complex mechanism of cytotoxicity for 7b includes abrogation of 5-FU-induced the S phase, reduction of the phosph …
DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer.
Jaiswal AS, Banerjee S, Aneja R, Sarkar FH, Ostrov DA, Narayan S. Jaiswal AS, et al. Among authors: narayan s. PLoS One. 2011 Feb 2;6(2):e16691. doi: 10.1371/journal.pone.0016691. PLoS One. 2011. PMID: 21311763 Free PMC article.
9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells.
Jaiswal AS, Aneja R, Connors SK, Joshi HC, Multani AS, Pathak S, Narayan S. Jaiswal AS, et al. Among authors: narayan s. J Cell Biochem. 2009 Apr 15;106(6):1146-56. doi: 10.1002/jcb.22099. J Cell Biochem. 2009. PMID: 19229861 Free PMC article.
A novel function of adenomatous polyposis coli (APC) in regulating DNA repair.
Jaiswal AS, Narayan S. Jaiswal AS, et al. Among authors: narayan s. Cancer Lett. 2008 Nov 28;271(2):272-80. doi: 10.1016/j.canlet.2008.06.024. Epub 2008 Jul 26. Cancer Lett. 2008. PMID: 18662849 Free PMC article. Review.
Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways.
Kundu CN, Balusu R, Jaiswal AS, Narayan S. Kundu CN, et al. Among authors: narayan s. Carcinogenesis. 2007 Oct;28(10):2089-95. doi: 10.1093/carcin/bgm125. Epub 2007 May 23. Carcinogenesis. 2007. PMID: 17522063
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