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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.
Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH. Hetz C, et al. Genes Dev. 2009 Oct 1;23(19):2294-306. doi: 10.1101/gad.1830709. Epub 2009 Sep 17. Genes Dev. 2009. PMID: 19762508 Free PMC article.
Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway.
Nassif M, Matus S, Castillo K, Hetz C. Nassif M, et al. Antioxid Redox Signal. 2010 Dec 15;13(12):1955-89. doi: 10.1089/ars.2009.2991. Epub 2010 Sep 1. Antioxid Redox Signal. 2010. PMID: 20560784 Review.
Targeting autophagy in ALS: a complex mission.
Nassif M, Hetz C. Nassif M, et al. Autophagy. 2011 Apr;7(4):450-3. doi: 10.4161/auto.7.4.14700. Epub 2011 Apr 1. Autophagy. 2011. PMID: 21252621
BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. Castillo K, et al. EMBO J. 2011 Sep 16;30(21):4465-78. doi: 10.1038/emboj.2011.318. EMBO J. 2011. PMID: 21926971 Free PMC article.
Autophagy impairment: a crossroad between neurodegeneration and tauopathies.
Nassif M, Hetz C. Nassif M, et al. BMC Biol. 2012 Sep 21;10:78. doi: 10.1186/1741-7007-10-78. BMC Biol. 2012. PMID: 22999309 Free PMC article.
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.
Castillo K, Nassif M, Valenzuela V, Rojas F, Matus S, Mercado G, Court FA, van Zundert B, Hetz C. Castillo K, et al. Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6. Autophagy. 2013. PMID: 23851366
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.
Nassif M, Valenzuela V, Rojas-Rivera D, Vidal R, Matus S, Castillo K, Fuentealba Y, Kroemer G, Levine B, Hetz C. Nassif M, et al. Autophagy. 2014 Jul;10(7):1256-71. doi: 10.4161/auto.28784. Epub 2014 May 12. Autophagy. 2014. PMID: 24905722 Free PMC article.
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model.
Bargsted L, Medinas DB, Martínez Traub F, Rozas P, Muñoz N, Nassif M, Jerez C, Catenaccio A, Court FA, Hetz C, Matus S. Bargsted L, et al. Sci Rep. 2017 Oct 27;7(1):14266. doi: 10.1038/s41598-017-14399-5. Sci Rep. 2017. PMID: 29079747 Free PMC article.
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