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Human endogenous retroviruses and the nervous system.
Douville RN, Nath A. Douville RN, et al. Among authors: nath a. Handb Clin Neurol. 2014;123:465-85. doi: 10.1016/B978-0-444-53488-0.00022-5. Handb Clin Neurol. 2014. PMID: 25015500 Free PMC article. Review. No abstract available.
Immunocytochemical and virological characteristics of HIV-associated inflammatory myopathies: similarities with seronegative polymyositis.
Illa I, Nath A, Dalakas M. Illa I, et al. Among authors: nath a. Ann Neurol. 1991 May;29(5):474-81. doi: 10.1002/ana.410290505. Ann Neurol. 1991. PMID: 1859178
A quantitative analysis of T cells and T-cell subsets, B cells, natural killer cells, interleukin-2 receptor-positive cells, and macrophages was performed on serial sections from all the specimens. ...The endomysial infiltrates in specimens from HIV-positive patients diffe
A quantitative analysis of T cells and T-cell subsets, B cells, natural killer cells, interleukin-2 receptor-positive cells, and macr
Influence of highly active antiretroviral therapy on persistence of HIV in the central nervous system.
Nath A, Sacktor N. Nath A, et al. Curr Opin Neurol. 2006 Aug;19(4):358-61. doi: 10.1097/01.wco.0000236614.51592.ca. Curr Opin Neurol. 2006. PMID: 16914973 Review.
This has had a significant impact on the neurological manifestations of HIV infection, posing new challenges in diagnosis and treatment. ...Although this antiretroviral therapy has had a significant impact on the severity of HIV dementia, cognitive impairment persis …
This has had a significant impact on the neurological manifestations of HIV infection, posing new challenges in diagnosis and treatme …
Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axons.
Hahn K, Robinson B, Anderson C, Li W, Pardo CA, Morgello S, Simpson D, Nath A. Hahn K, et al. Among authors: nath a. Exp Neurol. 2008 Mar;210(1):30-40. doi: 10.1016/j.expneurol.2007.06.015. Epub 2007 Jul 6. Exp Neurol. 2008. PMID: 18177640 Free PMC article.
To determine the role of HIV-infected macrophages in the pathogenesis of HIV-DSP, we developed a technique for culturing human DRG's. ...These observations suggest a differential effect on the axon and cell body. Different mechanisms of injury may be operative in th …
To determine the role of HIV-infected macrophages in the pathogenesis of HIV-DSP, we developed a technique for culturing human DRG's. …
Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis.
Douville R, Liu J, Rothstein J, Nath A. Douville R, et al. Among authors: nath a. Ann Neurol. 2011 Jan;69(1):141-51. doi: 10.1002/ana.22149. Ann Neurol. 2011. PMID: 21280084 Free PMC article.
Sequencing revealed several actively transcribed loci in the HML-2 and 3 subfamilies of HERV-K, with a specific pattern of expression including intact open reading frames and the transcription of a unique locus in ALS. ...HERV-K expression strongly correlated with T …
Sequencing revealed several actively transcribed loci in the HML-2 and 3 subfamilies of HERV-K, with a specific pattern of expression …
Neurological infections: risks of globalisation and new drugs.
Major EO, Nath A. Major EO, et al. Among authors: nath a. Lancet Neurol. 2012 Jan;11(1):14-5. doi: 10.1016/S1474-4422(11)70279-4. Lancet Neurol. 2012. PMID: 22172615 No abstract available.
Modeling HIV-associated neurocognitive disorders in mice: new approaches in the changing face of HIV neuropathogenesis.
Jaeger LB, Nath A. Jaeger LB, et al. Among authors: nath a. Dis Model Mech. 2012 May;5(3):313-22. doi: 10.1242/dmm.008763. Epub 2012 Mar 22. Dis Model Mech. 2012. PMID: 22563057 Free PMC article. Review.
Since the introduction of combined antiretroviral therapy (cART), the clinical presentation of HIV infection has evolved into a chronic illness with very low levels of viral replication and chronic immune activation, with compliant affected individuals surviving for decade …
Since the introduction of combined antiretroviral therapy (cART), the clinical presentation of HIV infection has evolved into a chron …
Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.
Ferenczy MW, Marshall LJ, Nelson CD, Atwood WJ, Nath A, Khalili K, Major EO. Ferenczy MW, et al. Among authors: nath a. Clin Microbiol Rev. 2012 Jul;25(3):471-506. doi: 10.1128/CMR.05031-11. Clin Microbiol Rev. 2012. PMID: 22763635 Free PMC article. Review.
Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which there is currently no effective treatment. ...Before the mid-1980s, PML was a relatively ra …
Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal central nervous system (CNS) demyelinating di …
Neurologic complications of HIV-1 infection and its treatment in the era of antiretroviral therapy.
Kranick SM, Nath A. Kranick SM, et al. Among authors: nath a. Continuum (Minneap Minn). 2012 Dec;18(6 Infectious Disease):1319-37. doi: 10.1212/01.CON.0000423849.24900.ec. Continuum (Minneap Minn). 2012. PMID: 23221843 Free PMC article. Review.
Efavirenz, a non-nucleoside reverse transcriptase inhibitor, has the greatest frequency of neurologic side effects among newer ART regimens. ...A greater understanding of pathophysiology and risk factors has shown that while HIV should be treated early to prevent se …
Efavirenz, a non-nucleoside reverse transcriptase inhibitor, has the greatest frequency of neurologic side effects among newer ART re …
Where does HIV hide? A focus on the central nervous system.
Churchill M, Nath A. Churchill M, et al. Among authors: nath a. Curr Opin HIV AIDS. 2013 May;8(3):165-9. doi: 10.1097/COH.0b013e32835fc601. Curr Opin HIV AIDS. 2013. PMID: 23429501 Free PMC article. Review.
The brain is a relatively immune privileged site and the blood-brain barrier prevents easy access to antiretroviral drugs. Further, the virus infects resident macrophages and astrocytes which are long-lived cells and causes minimal cytopathology in these cells. Hence as we …
The brain is a relatively immune privileged site and the blood-brain barrier prevents easy access to antiretroviral drugs. Further, t …
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