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Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement.
DiLorenzo TP, Graser RT, Ono T, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV. DiLorenzo TP, et al. Among authors: nathenson sg. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12538-43. doi: 10.1073/pnas.95.21.12538. Proc Natl Acad Sci U S A. 1998. PMID: 9770521 Free PMC article.
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.
Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP. Lieberman SM, et al. Among authors: nathenson sg. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8384-8. doi: 10.1073/pnas.0932778100. Epub 2003 Jun 18. Proc Natl Acad Sci U S A. 2003. PMID: 12815107 Free PMC article.
Structural analysis of H2-Db class I molecules containing two different allelic forms of the type 1 diabetes susceptibility factor beta-2 microglobulin: implications for the mechanism underlying variations in antigen presentation.
Roden MM, Brims DR, Fedorov AA, DiLorenzo TP, Almo SC, Nathenson SG. Roden MM, et al. Among authors: nathenson sg. Mol Immunol. 2006 Mar;43(9):1370-8. doi: 10.1016/j.molimm.2005.08.005. Epub 2005 Oct 17. Mol Immunol. 2006. PMID: 16229893
Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.
Brims DR, Qian J, Jarchum I, Mikesh L, Palmieri E, Ramagopal UA, Malashkevich VN, Chaparro RJ, Lund T, Hattori M, Shabanowitz J, Hunt DF, Nathenson SG, Almo SC, Dilorenzo TP. Brims DR, et al. Among authors: nathenson sg. Int Immunol. 2010 Mar;22(3):191-203. doi: 10.1093/intimm/dxp127. Epub 2010 Jan 21. Int Immunol. 2010. PMID: 20093428 Free PMC article.
219 results