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Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.
Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J. Yasuda A, et al. J Agric Food Chem. 2011 Feb 23;59(4):1470-6. doi: 10.1021/jf103820b. Epub 2011 Jan 12. J Agric Food Chem. 2011. PMID: 21226458
Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro.
Osakabe N, Yasuda A, Natsume M, Takizawa T, Terao J, Kondo K. Osakabe N, et al. Exp Biol Med (Maywood). 2002 Jan;227(1):51-6. doi: 10.1177/153537020222700109. Exp Biol Med (Maywood). 2002. PMID: 11788784
Polyphenols: Inflammation.
Natsume M. Natsume M. Curr Pharm Des. 2018;24(2):191-202. doi: 10.2174/1381612823666171109104141. Curr Pharm Des. 2018. PMID: 29119920 Review.
Cacao liquor procyanidins prevent postprandial hyperglycaemia by increasing glucagon-like peptide-1 activity and AMP-activated protein kinase in mice.
Yamashita Y, Okabe M, Natsume M, Ashida H. Yamashita Y, et al. J Nutr Sci. 2019 Jan 16;8:e2. doi: 10.1017/jns.2018.28. eCollection 2019. J Nutr Sci. 2019. PMID: 30719284 Free PMC article.
Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder.
Baba S, Natsume M, Yasuda A, Nakamura Y, Tamura T, Osakabe N, Kanegae M, Kondo K. Baba S, et al. J Nutr. 2007 Jun;137(6):1436-41. doi: 10.1093/jn/137.6.1436. J Nutr. 2007. PMID: 17513403 Clinical Trial.
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