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Natural flavonoids targeting deregulated cell cycle progression in cancer cells.
Singh RP, Agarwal R. Singh RP, et al. Curr Drug Targets. 2006 Mar;7(3):345-54. doi: 10.2174/138945006776055004. Curr Drug Targets. 2006. PMID: 16515531 Review.
In this regard, targeting deregulated cell cycle progression and its modulation by various natural and synthetic agents are gaining widespread attention in recent years to control the unchecked growth and proliferation in cancer
In this regard, targeting deregulated cell cycle progression and its modulation by various natural
Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression.
Wang Z, Li Y, Sarkar FH. Wang Z, et al. Curr Stem Cell Res Ther. 2010 Mar;5(1):74-80. doi: 10.2174/157488810790442813. Curr Stem Cell Res Ther. 2010. PMID: 19951255 Free PMC article. Review.
Reactive oxygen species (ROS) are known to serve as a second messenger in the intracellular signal transduction pathway for a variety of cellular processes, including inflammation, cell cycle progression, apoptosis, aging and cancer. Recently, ROS have …
Reactive oxygen species (ROS) are known to serve as a second messenger in the intracellular signal transduction pathway for a variety of cel …
Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells.
Malami I, Abdul AB, Abdullah R, Kassim NK, Rosli R, Yeap SK, Waziri P, Etti IC, Bello MB. Malami I, et al. PLoS One. 2017 Jan 19;12(1):e0170233. doi: 10.1371/journal.pone.0170233. eCollection 2017. PLoS One. 2017. PMID: 28103302 Free PMC article.
The expression of p53 is directly linked to a blockage of cell cycle progression at G0/G1 phase and upregulates Bax, cytochrome c, and caspase 3 while Bcl2 was deregulated. In this respect, apoptosis induction and DNA fragmentation were observed in tre …
The expression of p53 is directly linked to a blockage of cell cycle progression at G0/G1 phase and upregulates Bax, cy …
Prostate cancer chemoprevention by silibinin: bench to bedside.
Singh RP, Agarwal R. Singh RP, et al. Mol Carcinog. 2006 Jun;45(6):436-42. doi: 10.1002/mc.20223. Mol Carcinog. 2006. PMID: 16637061 Review.
One approach to reduce PCA incidence, growth and metastasis is prevention and intervention targeted towards mitogenic and survival signaling and cell-cycle regulation. This approach is based on the rationale that overexpression of receptor tyrosine kinases (R …
One approach to reduce PCA incidence, growth and metastasis is prevention and intervention targeted towards mitogenic and survival si …
Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics.
Fischer PM, Lane DP. Fischer PM, et al. Curr Med Chem. 2000 Dec;7(12):1213-45. doi: 10.2174/0929867003374048. Curr Med Chem. 2000. PMID: 11032968
Initiation, progression, and completion of the cell cycle are regulated by various cyclin-dependent kinases (CDKs), which are thus critical for cell growth. Tumour development is closely associated with genetic alteration and deregulation of CDK …
Initiation, progression, and completion of the cell cycle are regulated by various cyclin-dependent kinases (CDKs), whi …