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Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir.
Rameix-Welti MA, Agou F, Buchy P, Mardy S, Aubin JT, Véron M, van der Werf S, Naffakh N. Rameix-Welti MA, et al. Antimicrob Agents Chemother. 2006 Nov;50(11):3809-15. doi: 10.1128/AAC.00645-06. Epub 2006 Aug 28. Antimicrob Agents Chemother. 2006. PMID: 16940075 Free PMC article.
In this study, we compare the sensitivities to oseltamivir of the NAs of several highly pathogenic H5N1 viruses isolated in Asia from 1997 to 2005. ...Our data show that the sensitivities of the NAs of H5N1 viruses isolated in 2004 …
In this study, we compare the sensitivities to oseltamivir of the NAs of several highly pathogenic H5N1 viruses
Neuraminidase inhibitor sensitivity and receptor-binding specificity of Cambodian clade 1 highly pathogenic H5N1 influenza virus.
Naughtin M, Dyason JC, Mardy S, Sorn S, von Itzstein M, Buchy P. Naughtin M, et al. Antimicrob Agents Chemother. 2011 May;55(5):2004-10. doi: 10.1128/AAC.01773-10. Epub 2011 Feb 22. Antimicrob Agents Chemother. 2011. PMID: 21343450 Free PMC article.
The evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes in antiviral susceptibility and in receptor-binding specificity. ...We have observed naturally occurring mutations in hemaggl …
The evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes …