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1989 1
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Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals.
Legare CA, Raup-Konsavage WM, Vrana KE. Legare CA, et al. Pharmacology. 2022;107(3-4):131-149. doi: 10.1159/000521683. Epub 2022 Jan 28. Pharmacology. 2022. PMID: 35093949 Free article. Review.
BACKGROUND: There is a growing interest in the use of cannabis (and its extracts), as well as CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is reason to believe that cannabinoids may be efficacious for a number of different diseases …
BACKGROUND: There is a growing interest in the use of cannabis (and its extracts), as well as CBD oil (hemp extracts containing cannabidi
Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications.
Bilbao A, Spanagel R. Bilbao A, et al. BMC Med. 2022 Aug 19;20(1):259. doi: 10.1186/s12916-022-02459-1. BMC Med. 2022. PMID: 35982439 Free PMC article. Review.
METHODS: We systematically reviewed (registered at PROSPERO: CRD42021229932) eight databases for randomized controlled trials (RCTs) of dronabinol, nabilone, cannabidiol and nabiximols for chronic pain, spasticity, nausea /vomiting, appetite, ALS, irritable bowel sy …
METHODS: We systematically reviewed (registered at PROSPERO: CRD42021229932) eight databases for randomized controlled trials (RCTs) of dron …
Constituents of Cannabis Sativa.
Rock EM, Parker LA. Rock EM, et al. Adv Exp Med Biol. 2021;1264:1-13. doi: 10.1007/978-3-030-57369-0_1. Adv Exp Med Biol. 2021. PMID: 33332000 Review.
There are more than 550 chemical compounds in cannabis, with more than 100 phytocannabinoids being identified, including delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD). These phytocannabinoids work by binding to the cannabinoid receptors, as well as other recept …
There are more than 550 chemical compounds in cannabis, with more than 100 phytocannabinoids being identified, including delta(9)-tetrahydro …
Cannabinoids: Therapeutic Use in Clinical Practice.
Pagano C, Navarra G, Coppola L, Avilia G, Bifulco M, Laezza C. Pagano C, et al. Int J Mol Sci. 2022 Mar 19;23(6):3344. doi: 10.3390/ijms23063344. Int J Mol Sci. 2022. PMID: 35328765 Free PMC article. Review.
Today, FDA-approved drugs, such as nabiximols (a mixture of THC and non-psychoactive cannabidiol (CBD)), are employed in alleviating pain and spasticity in multiple sclerosis. Dronabinol and nabilone are used for the treatment of chemotherapy-induced nausea and vomi …
Today, FDA-approved drugs, such as nabiximols (a mixture of THC and non-psychoactive cannabidiol (CBD)), are employed in alleviating …
Therapeutic Potential of Cannabidiol, Cannabidiolic Acid, and Cannabidiolic Acid Methyl Ester as Treatments for Nausea and Vomiting.
Rock EM, Limebeer CL, Pertwee RG, Mechoulam R, Parker LA. Rock EM, et al. Cannabis Cannabinoid Res. 2021 Aug;6(4):266-274. doi: 10.1089/can.2021.0041. Epub 2021 Jun 11. Cannabis Cannabinoid Res. 2021. PMID: 34115951 Free PMC article. Review.
Introduction: Nausea and vomiting are the most distressing symptoms reported by oncology patients undergoing anticancer treatment. ...Discussion: Here we review in vitro and in vivo evidence for the effectiveness of the nonpsychoactive cannabinoid cannabidiol (CBD) …
Introduction: Nausea and vomiting are the most distressing symptoms reported by oncology patients undergoing anticancer treatment. .. …
Cannabidiol Interferes with Establishment of Δ9-Tetrahydrocannabinol-Induced Nausea Through a 5-HT1A Mechanism.
DeVuono MV, La Caprara O, Petrie GN, Limebeer CL, Rock EM, Hill MN, Parker LA. DeVuono MV, et al. Cannabis Cannabinoid Res. 2022 Feb;7(1):58-64. doi: 10.1089/can.2020.0083. Epub 2020 Dec 21. Cannabis Cannabinoid Res. 2022. PMID: 33998876 Free PMC article.
Cannabidiol (CBD), a nonpsychotropic compound found in cannabis, has been shown to interfere with some acute aversive effects of THC. In this study, we evaluated if CBD would interfere with THC-induced nausea through a 5-HT(1A) receptor mechanism as it has been show
Cannabidiol (CBD), a nonpsychotropic compound found in cannabis, has been shown to interfere with some acute aversive effects of THC.
Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses.
Breijyeh Z, Jubeh B, Bufo SA, Karaman R, Scrano L. Breijyeh Z, et al. Toxins (Basel). 2021 Feb 5;13(2):117. doi: 10.3390/toxins13020117. Toxins (Basel). 2021. PMID: 33562446 Free PMC article. Review.
Medical cannabis varies from recreational cannabis in the chemical content of THC and cannabidiol (CBD), modes of administration, and safety. Despite the therapeutic effects of cannabis, exposure to high concentrations of THC, the main compound that is responsible for most …
Medical cannabis varies from recreational cannabis in the chemical content of THC and cannabidiol (CBD), modes of administration, and …
Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial.
Grimison P, Mersiades A, Kirby A, Lintzeris N, Morton R, Haber P, Olver I, Walsh A, McGregor I, Cheung Y, Tognela A, Hahn C, Briscoe K, Aghmesheh M, Fox P, Abdi E, Clarke S, Della-Fiorentina S, Shannon J, Gedye C, Begbie S, Simes J, Stockler M. Grimison P, et al. Ann Oncol. 2020 Nov;31(11):1553-1560. doi: 10.1016/j.annonc.2020.07.020. Epub 2020 Aug 13. Ann Oncol. 2020. PMID: 32801017 Free article. Clinical Trial.
BACKGROUND: This multicentre, randomised, double-blinded, placebo-controlled, phase II/III trial aimed to evaluate an oral THC:CBD (tetrahydrocannabinol:cannabidiol) cannabis extract for prevention of refractory chemotherapy-induced nausea and vomiting (CINV). ...CO …
BACKGROUND: This multicentre, randomised, double-blinded, placebo-controlled, phase II/III trial aimed to evaluate an oral THC:CBD (tetrahyd …
Medical Use of Cannabinoids.
Fraguas-Sánchez AI, Torres-Suárez AI. Fraguas-Sánchez AI, et al. Drugs. 2018 Nov;78(16):1665-1703. doi: 10.1007/s40265-018-0996-1. Drugs. 2018. PMID: 30374797 Review.
Its involvement in several physiological processes is well known, such as in energy balance, appetite stimulation, blood pressure, pain modulation, embryogenesis, nausea and vomiting control, memory, learning and immune response, among others, as well as in pathological co …
Its involvement in several physiological processes is well known, such as in energy balance, appetite stimulation, blood pressure, pain modu …
Cannabis Use, Lung Cancer, and Related Issues.
Jett J, Stone E, Warren G, Cummings KM. Jett J, et al. J Thorac Oncol. 2018 Apr;13(4):480-487. doi: 10.1016/j.jtho.2017.12.013. Epub 2018 Jan 31. J Thorac Oncol. 2018. PMID: 29374567 Free article. Review.
Increasing evidence supports cannabis in the management of chemotherapy-induced nausea and vomiting (CINV) and for pain management; however, studies are limited, particularly by difficulties associated with standardized dosing estimates and inability to accurately assess b …
Increasing evidence supports cannabis in the management of chemotherapy-induced nausea and vomiting (CINV) and for pain management; h …
199 results