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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1998 1
1999 1
2001 2
2002 3
2003 2
2004 1
2005 1
2006 2
2007 2
2008 2
2009 2
2010 3
2011 4
2012 4
2013 8
2014 7
2015 8
2016 8
2017 9
2018 20
2019 14
2020 15
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Cannabinoids: the lows and the highs of chemotherapy-induced nausea and vomiting.
Mortimer TL, Mabin T, Engelbrecht AM. Mortimer TL, et al. Future Oncol. 2019 Mar;15(9):1035-1049. doi: 10.2217/fon-2018-0530. Epub 2019 Feb 5. Future Oncol. 2019. PMID: 30720344 Review.
The phytocannabinoids, cannabidiol and Δ-9-tetrahydrocannabinol, reduce nausea and vomiting, particularly during chemotherapy. ...Although there are many preclinical and clinical studies on the effects of Δ-9-tetrahydrocannabinol during nausea and vomiting, l …
The phytocannabinoids, cannabidiol and Δ-9-tetrahydrocannabinol, reduce nausea and vomiting, particularly during chemotherapy. …
Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol.
Limebeer CL, Rock EM, Sharkey KA, Parker LA. Limebeer CL, et al. eNeuro. 2018 Jul 31;5(4):ENEURO.0256-18.2018. doi: 10.1523/ENEURO.0256-18.2018. eCollection 2018 Jul-Aug. eNeuro. 2018. PMID: 30073198 Free PMC article.
Using the rat conditioned gaping model of nausea, the interoceptive insular cortex (IIC) has been identified as a critical site for the regulation of lithium chloride (LiCl)-induced nausea. ...Systemic cannabidiol (CBD), which reduces LiCl-induced nausea …
Using the rat conditioned gaping model of nausea, the interoceptive insular cortex (IIC) has been identified as a critical site for t …
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects.
Taylor L, Gidal B, Blakey G, Tayo B, Morrison G. Taylor L, et al. CNS Drugs. 2018 Nov;32(11):1053-1067. doi: 10.1007/s40263-018-0578-5. CNS Drugs. 2018. PMID: 30374683 Free PMC article. Clinical Trial.
BACKGROUND: A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose, and to examine the effect of food on CBD PK parameters. ...Diarrh …
BACKGROUND: A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to …
Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action.
Zuardi AW. Zuardi AW. Braz J Psychiatry. 2008 Sep;30(3):271-80. doi: 10.1590/s1516-44462008000300015. Braz J Psychiatry. 2008. PMID: 18833429 Free article. Review.
DISCUSSION: After the elucidation of the chemical structure of cannabidiol in 1963, the initial studies showed that cannabidiol was unable to mimic the effects of Cannabis. ...These studies have suggested a wide range of possible therapeutic effects of cannabidio …
DISCUSSION: After the elucidation of the chemical structure of cannabidiol in 1963, the initial studies showed that cannabidiol …
Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
Fernández-Ruiz J, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J. Fernández-Ruiz J, et al. Br J Clin Pharmacol. 2013 Feb;75(2):323-33. doi: 10.1111/j.1365-2125.2012.04341.x. Br J Clin Pharmacol. 2013. PMID: 22625422 Free PMC article. Review.
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic …
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that …
Cannabidiol: an overview of some pharmacological aspects.
Mechoulam R, Parker LA, Gallily R. Mechoulam R, et al. J Clin Pharmacol. 2002 Nov;42(S1):11S-19S. doi: 10.1002/j.1552-4604.2002.tb05998.x. J Clin Pharmacol. 2002. PMID: 12412831 Review.
Over the past few years, considerable attention has focused on cannabidiol (CBD), a major nonpsychotropic constituent of cannabis. ...
Over the past few years, considerable attention has focused on cannabidiol (CBD), a major nonpsychotropic constituent of cannabis. .. …
Medical Use of Cannabinoids.
Fraguas-Sánchez AI, Torres-Suárez AI. Fraguas-Sánchez AI, et al. Drugs. 2018 Nov;78(16):1665-1703. doi: 10.1007/s40265-018-0996-1. Drugs. 2018. PMID: 30374797 Review.
Its involvement in several physiological processes is well known, such as in energy balance, appetite stimulation, blood pressure, pain modulation, embryogenesis, nausea and vomiting control, memory, learning and immune response, among others, as well as in pathological co …
Its involvement in several physiological processes is well known, such as in energy balance, appetite stimulation, blood pressure, pain modu …
Oral cannabinoid-rich THC/CBD cannabis extract for secondary prevention of chemotherapy-induced nausea and vomiting: a study protocol for a pilot and definitive randomised double-blind placebo-controlled trial (CannabisCINV).
Mersiades AJ, Tognela A, Haber PS, Stockler M, Lintzeris N, Simes J, McGregor I, Olver I, Allsop DJ, Gedye C, Kirby AC, Morton RL, Fox P, Clarke S, Briscoe K, Aghmesheh M, Wong N, Walsh A, Hahn C, Grimison P. Mersiades AJ, et al. BMJ Open. 2018 Sep 12;8(9):e020745. doi: 10.1136/bmjopen-2017-020745. BMJ Open. 2018. PMID: 30209152 Free PMC article. Clinical Trial.
INTRODUCTION: Chemotherapy-induced nausea and vomiting (CINV) remains an important issue for patients receiving chemotherapy despite guideline-consistent antiemetic therapy. ...Trials using cannabidiol-rich (CBD) products demonstrate improved efficacy and psychologi …
INTRODUCTION: Chemotherapy-induced nausea and vomiting (CINV) remains an important issue for patients receiving chemotherapy despite …
Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol.
Kenyon J, Liu W, Dalgleish A. Kenyon J, et al. Anticancer Res. 2018 Oct;38(10):5831-5835. doi: 10.21873/anticanres.12924. Anticancer Res. 2018. PMID: 30275207
BACKGROUND/AIM: Cannabinoids are widely used in the management of pain, nausea and cachexia in cancer patients. However, there has been no objective clinical evidence of any anticancer activity yet. ...No side-effects of any kind were observed when using pharmaceutical gra …
BACKGROUND/AIM: Cannabinoids are widely used in the management of pain, nausea and cachexia in cancer patients. However, there has be …
Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer.
Pellati F, Borgonetti V, Brighenti V, Biagi M, Benvenuti S, Corsi L. Pellati F, et al. Biomed Res Int. 2018 Dec 4;2018:1691428. doi: 10.1155/2018/1691428. eCollection 2018. Biomed Res Int. 2018. PMID: 30627539 Free PMC article. Review.
., such as Δ(9)-tetrahydrocannabinol (Δ(9)-THC) and cannabidiol (CBD), and their effects on inflammation and cancer-related pain. The National Cancer Institute (NCI) currently recognizes medicinal C. sativa as an effective treatment for providing relief in a number of symp …
., such as Δ(9)-tetrahydrocannabinol (Δ(9)-THC) and cannabidiol (CBD), and their effects on inflammation and cancer-related pain. The …
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