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Nitazoxanide, tizoxanide and a new analogue [4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide; NTB] inhibit the growth of kinetoplastid parasites (Trypanosoma cruzi and Leishmania mexicana) in vitro.
Chan-Bacab MJ, Hernández-Núñez E, Navarrete-Vázquez G. Chan-Bacab MJ, et al. J Antimicrob Chemother. 2009 Jun;63(6):1292-3. doi: 10.1093/jac/dkp117. Epub 2009 Apr 4. J Antimicrob Chemother. 2009. PMID: 19346519 No abstract available.
Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity.
Navarrete-Vazquez G, Chávez-Silva F, Argotte-Ramos R, Rodríguez-Gutiérrez Mdel C, Chan-Bacab MJ, Cedillo-Rivera R, Moo-Puc R, Hernández-Nuñez E. Navarrete-Vazquez G, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3168-71. doi: 10.1016/j.bmcl.2011.02.100. Epub 2011 Feb 26. Bioorg Med Chem Lett. 2011. PMID: 21397502
Proton pump inhibitors drastically modify triosephosphate isomerase from Giardia lamblia at functional and structural levels, providing molecular leads in the design of new antigiardiasic drugs.
García-Torres I, de la Mora-de la Mora I, Marcial-Quino J, Gómez-Manzo S, Vanoye-Carlo A, Navarrete-Vázquez G, Colín-Lozano B, Gutiérrez-Castrellón P, Sierra-Palacios E, López-Velázquez G, Enríquez-Flores S. García-Torres I, et al. Biochim Biophys Acta. 2016 Jan;1860(1 Pt A):97-107. doi: 10.1016/j.bbagen.2015.10.021. Epub 2015 Oct 28. Biochim Biophys Acta. 2016. PMID: 26518348
Antiprotozoal Nitazoxanide Derivatives: Synthesis, Bioassays and QSAR Study Combined with Docking for Mechanistic Insight.
Scior T, Lozano-Aponte J, Ajmani S, Hernández-Montero E, Chávez-Silva F, Hernández-Núñez E, Moo-Puc R, Fraguela-Collar A, Navarrete-Vázquez G. Scior T, et al. Curr Comput Aided Drug Des. 2015;11(1):21-31. doi: 10.2174/1573409911666150414145937. Curr Comput Aided Drug Des. 2015. PMID: 25872791 Free PMC article.
Activity and property landscape modeling is at the interface of chemoinformatics and medicinal chemistry.
Medina-Franco JL, Navarrete-Vázquez G, Méndez-Lucio O. Medina-Franco JL, et al. Future Med Chem. 2015;7(9):1197-211. doi: 10.4155/fmc.15.51. Future Med Chem. 2015. PMID: 26132526 Review.
Synthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents.
Romero-Castro A, León-Rivera I, Avila-Rojas LC, Navarrete-Vázquez G, Nieto-Rodríguez A. Romero-Castro A, et al. Arch Pharm Res. 2011 Feb;34(2):181-9. doi: 10.1007/s12272-011-0201-5. Epub 2011 Mar 6. Arch Pharm Res. 2011. PMID: 21380799
In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.
Cerón-Romero L, Paoli P, Camici G, Flores-Morales V, Rios MY, Ramírez-Espinosa JJ, Hidalgo-Figueroa S, Navarrete-Vázquez G, Estrada-Soto S. Cerón-Romero L, et al. Bioorg Med Chem Lett. 2016 Apr 15;26(8):2018-22. doi: 10.1016/j.bmcl.2016.02.082. Epub 2016 Mar 3. Bioorg Med Chem Lett. 2016. PMID: 26961283
Evaluation of the neuroprotective activity of stansin 6, a resin glycoside from Ipomoea stans.
León-Rivera I, Villeda-Hernández J, Campos-Peña V, Aguirre-Moreno A, Estrada-Soto S, Navarrete-Vázquez G, Rios MY, Aguilar-Guadarrama B, Castillo-España P, Rivera-Leyva JC. León-Rivera I, et al. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3541-5. doi: 10.1016/j.bmcl.2014.05.055. Epub 2014 May 27. Bioorg Med Chem Lett. 2014. PMID: 24928403
Discovery of thiazolidine-2,4-dione/biphenylcarbonitrile hybrid as dual PPAR α/γ modulator with antidiabetic effect: in vitro, in silico and in vivo approaches.
Hidalgo-Figueroa S, Ramírez-Espinosa JJ, Estrada-Soto S, Almanza-Pérez JC, Román-Ramos R, Alarcón-Aguilar FJ, Hernández-Rosado JV, Moreno-Díaz H, Díaz-Coutiño D, Navarrete-Vázquez G. Hidalgo-Figueroa S, et al. Chem Biol Drug Des. 2013 Apr;81(4):474-83. doi: 10.1111/cbdd.12102. Epub 2013 Mar 21. Chem Biol Drug Des. 2013. PMID: 23289972
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.
Ramírez-Espinosa JJ, Rios MY, López-Martínez S, López-Vallejo F, Medina-Franco JL, Paoli P, Camici G, Navarrete-Vázquez G, Ortiz-Andrade R, Estrada-Soto S. Ramírez-Espinosa JJ, et al. Eur J Med Chem. 2011 Jun;46(6):2243-51. doi: 10.1016/j.ejmech.2011.03.005. Epub 2011 Mar 30. Eur J Med Chem. 2011. PMID: 21453996
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