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Na+ controls hypoxic signalling by the mitochondrial respiratory chain.
Hernansanz-Agustín P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Piña T, Moreno L, Izquierdo-Álvarez A, Cabrera-García JD, Cortés A, Lechuga-Vieco AV, Jadiya P, Navarro E, Parada E, Palomino-Antolín A, Tello D, Acín-Pérez R, Rodríguez-Aguilera JC, Navas P, Cogolludo Á, López-Montero I, Martínez-Del-Pozo Á, Egea J, López MG, Elrod JW, Ruíz-Cabello J, Bogdanova A, Enríquez JA, Martínez-Ruiz A. Hernansanz-Agustín P, et al. Among authors: navarro e. Nature. 2020 Oct;586(7828):287-291. doi: 10.1038/s41586-020-2551-y. Epub 2020 Jul 29. Nature. 2020. PMID: 32728214 Free PMC article.
Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia.
Hernansanz-Agustín P, Ramos E, Navarro E, Parada E, Sánchez-López N, Peláez-Aguado L, Cabrera-García JD, Tello D, Buendia I, Marina A, Egea J, López MG, Bogdanova A, Martínez-Ruiz A. Hernansanz-Agustín P, et al. Among authors: navarro e. Redox Biol. 2017 Aug;12:1040-1051. doi: 10.1016/j.redox.2017.04.025. Epub 2017 Apr 21. Redox Biol. 2017. PMID: 28511347 Free PMC article.
The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation, and mitochondrial abnormalities.
Martin-de-Saavedra MD, Navarro E, Moreno-Ortega AJ, Cunha MP, Buendia I, Hernansanz-Agustín P, León R, Cano-Abad MF, Martínez-Ruiz A, Martínez-Murillo R, Duchen MR, López MG. Martin-de-Saavedra MD, et al. Among authors: navarro e. J Neurochem. 2018 Apr;145(2):170-182. doi: 10.1111/jnc.14293. Epub 2018 Feb 12. J Neurochem. 2018. PMID: 29315575 Free article.
661 results