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Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine.
Galisteo J, Navarro P, Campayo L, Yunta MJ, Gómez-Contreras F, Villa-Pulgarin JA, Sierra BG, Mollinedo F, Gonzalez J, Garcia-España E. Galisteo J, et al. Among authors: navarro p. Bioorg Med Chem. 2010 Jul 15;18(14):5301-9. doi: 10.1016/j.bmc.2010.05.053. Epub 2010 May 24. Bioorg Med Chem. 2010. PMID: 20538470
1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi.
Rodríguez-Ciria M, Sanz AM, Yunta MJ, Gómez-Contreras F, Navarro P, Sánchez-Moreno M, Boutaleb-Charki S, Osuna A, Castiñeiras A, Pardo M, Cano C, Campayo L. Rodríguez-Ciria M, et al. Among authors: navarro p. Bioorg Med Chem. 2007 Mar 1;15(5):2081-91. doi: 10.1016/j.bmc.2006.12.033. Epub 2006 Dec 23. Bioorg Med Chem. 2007. PMID: 17222558
Efficient inhibition of iron superoxide dismutase and of Trypanosoma cruzi growth by benzo[g]phthalazine derivatives functionalized with one or two imidazole rings.
Sanz AM, Gómez-Contreras F, Navarro P, Sánchez-Moreno M, Boutaleb-Charki S, Campuzano J, Pardo M, Osuna A, Cano C, Yunta MJ, Campayo L. Sanz AM, et al. Among authors: navarro p. J Med Chem. 2008 Mar 27;51(6):1962-6. doi: 10.1021/jm701179m. Epub 2008 Feb 23. J Med Chem. 2008. PMID: 18293910
846 results