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Developmental biology and tissue engineering.
Marga F, Neagu A, Kosztin I, Forgacs G. Marga F, et al. Birth Defects Res C Embryo Today. 2007 Dec;81(4):320-8. doi: 10.1002/bdrc.20109. Birth Defects Res C Embryo Today. 2007. PMID: 18228266 Review.
To accomplish this goal more naturally and efficiently, we set up and implemented a novel TE method that is based on principles of developmental biology and employs bioprinting, the automated delivery of cellular composites into a three-dimensional (3D) biocompatibl …
To accomplish this goal more naturally and efficiently, we set up and implemented a novel TE method that is based on principles of de …
Engineering biological structures of prescribed shape using self-assembling multicellular systems.
Jakab K, Neagu A, Mironov V, Markwald RR, Forgacs G. Jakab K, et al. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2864-9. doi: 10.1073/pnas.0400164101. Epub 2004 Feb 23. Proc Natl Acad Sci U S A. 2004. PMID: 14981244 Free PMC article.
Depending on the properties of the gel, upon incubation, the aggregates either fused into a toroidal 3D structure or their constituent cells dispersed into the surrounding matrix. ...The model-based analysis also revealed that the observed toroidal structure represents …
Depending on the properties of the gel, upon incubation, the aggregates either fused into a toroidal 3D structure or their constituen …
Organ printing: fiction or science.
Jakab K, Neagu A, Mironov V, Forgacs G. Jakab K, et al. Biorheology. 2004;41(3-4):371-5. Biorheology. 2004. PMID: 15299269
Here we show that based on these properties three-dimensional cellular structures of prescribed shape can be constructed by a novel method: cell aggregate printing. ...To elucidate the driving force and optimal conditions for this pattern formation, Monte Carlo simulations …
Here we show that based on these properties three-dimensional cellular structures of prescribed shape can be constructed by a novel m …
Role of physical mechanisms in biological self-organization.
Neagu A, Jakab K, Jamison R, Forgacs G. Neagu A, et al. Phys Rev Lett. 2005 Oct 21;95(17):178104. doi: 10.1103/PhysRevLett.95.178104. Epub 2005 Oct 21. Phys Rev Lett. 2005. PMID: 16383876
Morphogenesis is under strict genetic control, but shape evolution itself is a physical process. Here we report the results of experimental and modeling biophysical studies on in vitro biological structure formation. ...Our work suggests a novel way to engineer biol …
Morphogenesis is under strict genetic control, but shape evolution itself is a physical process. Here we report the results of experi …
Three-dimensional tissue constructs built by bioprinting.
Jakab K, Damon B, Neagu A, Kachurin A, Forgacs G. Jakab K, et al. Biorheology. 2006;43(3,4):509-13. Biorheology. 2006. PMID: 16912422
In the latter case a mixture of cells and scaffold material is extruded from the biocartridge akin to toothpaste to arrive at the desired construct. ...
In the latter case a mixture of cells and scaffold material is extruded from the biocartridge akin to toothpaste to arrive at the des …
Relating biophysical properties across scales.
Flenner E, Marga F, Neagu A, Kosztin I, Forgacs G. Flenner E, et al. Curr Top Dev Biol. 2008;81:461-83. doi: 10.1016/S0070-2153(07)81016-7. Curr Top Dev Biol. 2008. PMID: 18023738 Review.
A distinguishing feature of a multicellular living system is that it operates at various scales, from the intracellular to organismal. ...Our approach has validity beyond the particular morphogenetic process considered here and provides a general way to relat
A distinguishing feature of a multicellular living system is that it operates at various scales, from the intracellular to org
Tissue engineering by self-assembly of cells printed into topologically defined structures.
Jakab K, Norotte C, Damon B, Marga F, Neagu A, Besch-Williford CL, Kachurin A, Church KH, Park H, Mironov V, Markwald R, Vunjak-Novakovic G, Forgacs G. Jakab K, et al. Tissue Eng Part A. 2008 Mar;14(3):413-21. doi: 10.1089/tea.2007.0173. Tissue Eng Part A. 2008. PMID: 18333793
In our technology, multicellular spheroids (bio-ink particles) are placed into biocompatible environment (bio-paper) by the use of a three-dimensional delivery device (bio-printer). ...
In our technology, multicellular spheroids (bio-ink particles) are placed into biocompatible environment (bio-paper) by the use of a
Computational modeling of epithelial-mesenchymal transformations.
Neagu A, Mironov V, Kosztin I, Barz B, Neagu M, Moreno-Rodriguez RA, Markwald RR, Forgacs G. Neagu A, et al. Biosystems. 2010 Apr;100(1):23-30. doi: 10.1016/j.biosystems.2009.12.004. Epub 2009 Dec 31. Biosystems. 2010. PMID: 20005917 Free PMC article.
Our results show that an EMT is promoted more efficiently by an increase in cell-substrate adhesion than by a decrease in cell-cell adhesion. ...We conclude that in order to maintain epithelial integrity during EMT the number of epithelial cells must increase at a c …
Our results show that an EMT is promoted more efficiently by an increase in cell-substrate adhesion than by a decrease in cell-cell a …
Cell seeding of tissue engineering scaffolds studied by Monte Carlo simulations.
Robu A, Neagu A, Stoicu-Tivadar L. Robu A, et al. Stud Health Technol Inform. 2011;169:882-6. Stud Health Technol Inform. 2011. PMID: 21893873
In a well-established approach to TE, cells are cultured on a biocompatible porous structure, called scaffold. Cell seeding of scaffolds is an important first step. Here we study conditions that assure a uniform and rapid distribution of cells within the scaf …
In a well-established approach to TE, cells are cultured on a biocompatible porous structure, called scaffold. Cell seeding of …
Kinetic Monte Carlo and cellular particle dynamics simulations of multicellular systems.
Flenner E, Janosi L, Barz B, Neagu A, Forgacs G, Kosztin I. Flenner E, et al. Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Mar;85(3 Pt 1):031907. doi: 10.1103/PhysRevE.85.031907. Epub 2012 Mar 8. Phys Rev E Stat Nonlin Soft Matter Phys. 2012. PMID: 22587123
Here we formulate two computer simulation methods: (1) a kinetic Monte Carlo (KMC) and (2) a cellular particle dynamics (CPD) method, which are capable of describing and predicting the shape evolution in time of three-dimensional multicellular systems during their b …
Here we formulate two computer simulation methods: (1) a kinetic Monte Carlo (KMC) and (2) a cellular particle dynamics (CPD) …
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