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Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.
Bowers PM, Verdino P, Wang Z, da Silva Correia J, Chhoa M, Macondray G, Do M, Neben TY, Horlick RA, Stanfield RL, Wilson IA, King DJ. Bowers PM, et al. Among authors: neben ty. J Biol Chem. 2014 Nov 28;289(48):33557-67. doi: 10.1074/jbc.M114.607176. Epub 2014 Oct 15. J Biol Chem. 2014. PMID: 25320089 Free PMC article.
Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies.
Bowers PM, Horlick RA, Neben TY, Toobian RM, Tomlinson GL, Dalton JL, Jones HA, Chen A, Altobell L 3rd, Zhang X, Macomber JL, Krapf IP, Wu BF, McConnell A, Chau B, Holland T, Berkebile AD, Neben SS, Boyle WJ, King DJ. Bowers PM, et al. Among authors: neben ty. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20455-60. doi: 10.1073/pnas.1114010108. Epub 2011 Dec 7. Proc Natl Acad Sci U S A. 2011. PMID: 22158898 Free PMC article.
High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation.
McConnell AD, Do M, Neben TY, Spasojevic V, MacLaren J, Chen AP, Altobell L 3rd, Macomber JL, Berkebile AD, Horlick RA, Bowers PM, King DJ. McConnell AD, et al. Among authors: neben ty. PLoS One. 2012;7(11):e49458. doi: 10.1371/journal.pone.0049458. Epub 2012 Nov 14. PLoS One. 2012. PMID: 23166676 Free PMC article.
Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation.
Bowers PM, Neben TY, Tomlinson GL, Dalton JL, Altobell L, Zhang X, Macomber JL, Wu BF, Toobian RM, McConnell AD, Verdino P, Chau B, Horlick RA, King DJ. Bowers PM, et al. Among authors: neben ty. J Biol Chem. 2013 Mar 15;288(11):7688-7696. doi: 10.1074/jbc.M112.445502. Epub 2013 Jan 25. J Biol Chem. 2013. PMID: 23355464 Free PMC article.
Mammalian cell display for the discovery and optimization of antibody therapeutics.
Bowers PM, Horlick RA, Kehry MR, Neben TY, Tomlinson GL, Altobell L, Zhang X, Macomber JL, Krapf IP, Wu BF, McConnell AD, Chau B, Berkebile AD, Hare E, Verdino P, King DJ. Bowers PM, et al. Among authors: neben ty. Methods. 2014 Jan 1;65(1):44-56. doi: 10.1016/j.ymeth.2013.06.010. Epub 2013 Jun 20. Methods. 2014. PMID: 23792919
Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models.
Kumar S, Ghosh S, Sharma G, Wang Z, Kehry MR, Marino MH, Neben TY, Lu S, Luo S, Roberts S, Ramaswamy S, Danaee H, Jenkins D. Kumar S, et al. Among authors: neben ty. MAbs. 2021 Jan-Dec;13(1):1954136. doi: 10.1080/19420862.2021.1954136. MAbs. 2021. PMID: 34313545 Free PMC article.
19 results