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384 results
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Hsp90 inhibitors as novel cancer chemotherapeutic agents.
Neckers L. Neckers L. Trends Mol Med. 2002;8(4 Suppl):S55-61. doi: 10.1016/s1471-4914(02)02316-x. Trends Mol Med. 2002. PMID: 11927289 Review.
Dynamics-Based Discovery of Allosteric Inhibitors: Selection of New Ligands for the C-terminal Domain of Hsp90.
Morra G, Neves MA, Plescia CJ, Tsustsumi S, Neckers L, Verkhivker G, Altieri DC, Colombo G. Morra G, et al. Among authors: neckers l. J Chem Theory Comput. 2010 Sep 14;6(9):2978-89. doi: 10.1021/ct100334n. Epub 2010 Aug 30. J Chem Theory Comput. 2010. PMID: 26616092 Free PMC article.
Molecular diagnosis and therapy of kidney cancer.
Linehan WM, Bratslavsky G, Pinto PA, Schmidt LS, Neckers L, Bottaro DP, Srinivasan R. Linehan WM, et al. Among authors: neckers l. Annu Rev Med. 2010;61:329-43. doi: 10.1146/annurev.med.042808.171650. Annu Rev Med. 2010. PMID: 20059341 Free PMC article. Review.
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.
Neckers L, Blagg B, Haystead T, Trepel JB, Whitesell L, Picard D. Neckers L, et al. Cell Stress Chaperones. 2018 Jul;23(4):467-482. doi: 10.1007/s12192-018-0877-2. Epub 2018 Feb 1. Cell Stress Chaperones. 2018. PMID: 29392504 Free PMC article. Review.
HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.
Kijima T, Prince TL, Tigue ML, Yim KH, Schwartz H, Beebe K, Lee S, Budzynski MA, Williams H, Trepel JB, Sistonen L, Calderwood S, Neckers L. Kijima T, et al. Among authors: neckers l. Sci Rep. 2018 May 3;8(1):6976. doi: 10.1038/s41598-018-25404-w. Sci Rep. 2018. PMID: 29725069 Free PMC article.
Gr(i)p the ER to Stress Out Melanoma.
Xu W, Neckers L. Xu W, et al. Among authors: neckers l. Cancer Cell. 2016 Jun 13;29(6):769-771. doi: 10.1016/j.ccell.2016.05.006. Cancer Cell. 2016. PMID: 27300428
The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activity.
Xu W, Neckers L. Xu W, et al. Among authors: neckers l. Future Oncol. 2012 Aug;8(8):939-42. doi: 10.2217/fon.12.80. Future Oncol. 2012. PMID: 22894668 Free PMC article.
A network of its own: the unique interactome of the Hsp90 cochaperone, Sba1/p23.
Prince T, Neckers L. Prince T, et al. Among authors: neckers l. Mol Cell. 2011 Jul 22;43(2):159-60. doi: 10.1016/j.molcel.2011.07.005. Mol Cell. 2011. PMID: 21777805 Free PMC article.
Detecting HSP90 phosphorylation.
Mollapour M, Neckers L. Mollapour M, et al. Among authors: neckers l. Methods Mol Biol. 2011;787:67-74. doi: 10.1007/978-1-61779-295-3_5. Methods Mol Biol. 2011. PMID: 21898227 Free PMC article.
Hsp90 in Cancer: Transcriptional Roles in the Nucleus.
Calderwood SK, Neckers L. Calderwood SK, et al. Among authors: neckers l. Adv Cancer Res. 2016;129:89-106. doi: 10.1016/bs.acr.2015.08.002. Epub 2015 Oct 12. Adv Cancer Res. 2016. PMID: 26916002 Free PMC article. Review.
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