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In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery.
Prakash C, Sharma R, Gleave M, Nedderman A. Prakash C, et al. Among authors: nedderman a. Curr Drug Metab. 2008 Nov;9(9):952-64. doi: 10.2174/138920008786485209. Curr Drug Metab. 2008. PMID: 18991592
The use of accelerator MS in support of MIST.
Nedderman A. Nedderman A. Bioanalysis. 2011 Dec;3(24):2695-9. doi: 10.4155/bio.11.269. Bioanalysis. 2011. PMID: 22185266 No abstract available.
A holistic strategy for characterizing the safety of metabolites through drug discovery and development.
Walker D, Brady J, Dalvie D, Davis J, Dowty M, Duncan JN, Nedderman A, Obach RS, Wright P. Walker D, et al. Among authors: nedderman a. Chem Res Toxicol. 2009 Oct;22(10):1653-62. doi: 10.1021/tx900213j. Chem Res Toxicol. 2009. PMID: 19715349 Review.
Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA. Dalvie D, et al. Among authors: nedderman a. Chem Res Toxicol. 2009 Feb;22(2):357-68. doi: 10.1021/tx8004357. Chem Res Toxicol. 2009. PMID: 19146377
Analytical strategies for identifying drug metabolites.
Prakash C, Shaffer CL, Nedderman A. Prakash C, et al. Among authors: nedderman a. Mass Spectrom Rev. 2007 May-Jun;26(3):340-69. doi: 10.1002/mas.20128. Mass Spectrom Rev. 2007. PMID: 17405144 Review.
Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?
Obach RS, Nedderman AN, Smith DA. Obach RS, et al. Among authors: nedderman an. Xenobiotica. 2012 Jan;42(1):46-56. doi: 10.3109/00498254.2011.621985. Epub 2011 Oct 12. Xenobiotica. 2012. PMID: 21992031 Review.
Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers.
Vourvahis M, Gleave M, Nedderman AN, Hyland R, Gardner I, Howard M, Kempshall S, Collins C, LaBadie R. Vourvahis M, et al. Among authors: nedderman an. Drug Metab Dispos. 2010 May;38(5):789-800. doi: 10.1124/dmd.109.031252. Epub 2010 Feb 2. Drug Metab Dispos. 2010. PMID: 20124396 Clinical Trial.
From definition to implementation: a cross-industry perspective of past, current and future MIST strategies.
Nedderman AN, Dear GJ, North S, Obach RS, Higton D. Nedderman AN, et al. Xenobiotica. 2011 Aug;41(8):605-22. doi: 10.3109/00498254.2011.562330. Epub 2011 Mar 29. Xenobiotica. 2011. PMID: 21446837 Review.
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Schadt S, Bister B, Chowdhury SK, Funk C, Hop CECA, Humphreys WG, Igarashi F, James AD, Kagan M, Khojasteh SC, Nedderman ANR, Prakash C, Runge F, Scheible H, Spracklin DK, Swart P, Tse S, Yuan J, Obach RS. Schadt S, et al. Among authors: nedderman anr. Drug Metab Dispos. 2018 Jun;46(6):865-878. doi: 10.1124/dmd.117.079848. Epub 2018 Feb 27. Drug Metab Dispos. 2018. PMID: 29487142 Review.
Metabolites in safety testing: metabolite identification strategies in discovery and development.
Nedderman AN. Nedderman AN. Biopharm Drug Dispos. 2009 May;30(4):153-62. doi: 10.1002/bdd.660. Biopharm Drug Dispos. 2009. PMID: 19544286
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