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Profiling proteasome activity in tissue with fluorescent probes.
Berkers CR, van Leeuwen FW, Groothuis TA, Peperzak V, van Tilburg EW, Borst J, Neefjes JJ, Ovaa H. Berkers CR, et al. Mol Pharm. 2007 Sep-Oct;4(5):739-48. doi: 10.1021/mp0700256. Epub 2007 Aug 21. Mol Pharm. 2007. PMID: 17708652
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.
Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, Neefjes J, van den Berg TK, Brummelkamp TR, Leusen JHW, Scheeren FA, Schumacher TN. Logtenberg MEW, et al. Nat Med. 2019 Apr;25(4):612-619. doi: 10.1038/s41591-019-0356-z. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833751 Free PMC article.
Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation.
Döring M, Blees H, Koller N, Tischer-Zimmermann S, Müsken M, Henrich F, Becker J, Grabski E, Wang J, Janssen H, Zuschratter W, Neefjes J, Klawonn F, Eiz-Vesper B, Tampé R, Kalinke U. Döring M, et al. Blood Adv. 2019 Mar 26;3(6):839-850. doi: 10.1182/bloodadvances.2018027268. Blood Adv. 2019. PMID: 30867143 Free PMC article.
Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.
Wijdeven RH, Janssen H, Nahidiazar L, Janssen L, Jalink K, Berlin I, Neefjes J. Wijdeven RH, et al. Nat Commun. 2016 Jun 10;7:11808. doi: 10.1038/ncomms11808. Nat Commun. 2016. PMID: 27283760 Free PMC article.
USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7.
Sapmaz A, Berlin I, Bos E, Wijdeven RH, Janssen H, Konietzny R, Akkermans JJ, Erson-Bensan AE, Koning RI, Kessler BM, Neefjes J, Ovaa H. Sapmaz A, et al. Nat Commun. 2019 Mar 29;10(1):1454. doi: 10.1038/s41467-019-09437-x. Nat Commun. 2019. PMID: 30926795 Free PMC article.
Chemical profiling of the genome with anti-cancer drugs defines target specificities.
Pang B, de Jong J, Qiao X, Wessels LF, Neefjes J. Pang B, et al. Nat Chem Biol. 2015 Jul;11(7):472-80. doi: 10.1038/nchembio.1811. Epub 2015 May 11. Nat Chem Biol. 2015. PMID: 25961671
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.
Kuijl C, Savage ND, Marsman M, Tuin AW, Janssen L, Egan DA, Ketema M, van den Nieuwendijk R, van den Eeden SJ, Geluk A, Poot A, van der Marel G, Beijersbergen RL, Overkleeft H, Ottenhoff TH, Neefjes J. Kuijl C, et al. Nature. 2007 Nov 29;450(7170):725-30. doi: 10.1038/nature06345. Nature. 2007. PMID: 18046412
Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing.
Koppers-Lalic D, Reits EA, Ressing ME, Lipinska AD, Abele R, Koch J, Marcondes Rezende M, Admiraal P, van Leeuwen D, Bienkowska-Szewczyk K, Mettenleiter TC, Rijsewijk FA, Tampé R, Neefjes J, Wiertz EJ. Koppers-Lalic D, et al. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5144-9. doi: 10.1073/pnas.0501463102. Epub 2005 Mar 25. Proc Natl Acad Sci U S A. 2005. PMID: 15793001 Free PMC article.
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