Neel BG - Search Results

1

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.

Yang W, Wang J, Moore DC, Liang H, Dooner M, Wu Q, Terek R, Chen Q, Ehrlich MG, Quesenberry PJ, Neel BG. Yang W, et al. Among authors: neel bg. Nature. 2013 Jul 25;499(7459):491-5. doi: 10.1038/nature12396. Epub 2013 Jul 17. Nature. 2013. PMID: 23863940 Free PMC article.

2

From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis.

Yang W, Neel BG. Yang W, et al. Among authors: neel bg. Rare Dis. 2013 Oct 2;1:e26657. doi: 10.4161/rdis.26657. eCollection 2013. Rare Dis. 2013. PMID: 25003010 Free PMC article.

3

SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity.

Zuo C, Wang L, Kamalesh RM, Bowen ME, Moore DC, Dooner MS, Reginato AM, Wu Q, Schorl C, Song Y, Warman ML, Neel BG, Ehrlich MG, Yang W. Zuo C, et al. Among authors: neel bg. Bone Res. 2018 Apr 6;6:12. doi: 10.1038/s41413-018-0013-z. eCollection 2018. Bone Res. 2018. PMID: 29644115 Free PMC article.

4

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.

Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG. Araki T, et al. Among authors: neel bg. Nat Med. 2004 Aug;10(8):849-57. doi: 10.1038/nm1084. Epub 2004 Jul 25. Nat Med. 2004. PMID: 15273746

5

A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.

Wang L, Iorio C, Yan K, Yang H, Takeshita S, Kang S, Neel BG, Yang W. Wang L, et al. Among authors: neel bg. FASEB J. 2018 Feb;32(2):875-887. doi: 10.1096/fj.201700672RR. Epub 2018 Jan 4. FASEB J. 2018. PMID: 29046360 Free PMC article.

6

Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.

Liu X, Zheng H, Li X, Wang S, Meyerson HJ, Yang W, Neel BG, Qu CK. Liu X, et al. Among authors: neel bg. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):984-9. doi: 10.1073/pnas.1508535113. Epub 2016 Jan 11. Proc Natl Acad Sci U S A. 2016. PMID: 26755576 Free PMC article.

7

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.

Yang W, Klaman LD, Chen B, Araki T, Harada H, Thomas SM, George EL, Neel BG. Yang W, et al. Among authors: neel bg. Dev Cell. 2006 Mar;10(3):317-27. doi: 10.1016/j.devcel.2006.01.002. Dev Cell. 2006. PMID: 16516835 Free article.

8

SHP2 is required for BCR-ABL1-induced hematologic neoplasia.

Gu S, Sayad A, Chan G, Yang W, Lu Z, Virtanen C, Van Etten RA, Neel BG. Gu S, et al. Among authors: neel bg. Leukemia. 2018 Jan;32(1):203-213. doi: 10.1038/leu.2017.250. Epub 2017 Aug 14. Leukemia. 2018. PMID: 28804122 Free PMC article.

9

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.

Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS. Chan G, et al. Among authors: neel bg. Blood. 2011 Apr 21;117(16):4253-61. doi: 10.1182/blood-2010-11-319517. Epub 2011 Feb 25. Blood. 2011. PMID: 21398220 Free PMC article.

10

Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.

Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG. Kontaridis MI, et al. Among authors: neel bg. Circulation. 2008 Mar 18;117(11):1423-35. doi: 10.1161/CIRCULATIONAHA.107.728865. Epub 2008 Mar 3. Circulation. 2008. PMID: 18316486 Free PMC article.

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