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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 1
1988 3
1989 2
1990 3
1991 10
1992 3
1993 11
1994 20
1995 30
1996 49
1997 68
1998 104
1999 138
2000 166
2001 242
2002 263
2003 251
2004 265
2005 305
2006 290
2007 319
2008 318
2009 320
2010 344
2011 382
2012 406
2013 407
2014 386
2015 418
2016 435
2017 490
2018 488
2019 490
2020 375
2021 64
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Negative Regulation of Cytokine Signaling in Immunity.
Yoshimura A, Ito M, Chikuma S, Akanuma T, Nakatsukasa H. Yoshimura A, et al. Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):a028571. doi: 10.1101/cshperspect.a028571. Cold Spring Harb Perspect Biol. 2018. PMID: 28716890 Free PMC article. Review.
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to promote gene transcriptional regulation, but their signals must be attenuated by mu
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of
Evolution of Cytokine Receptor Signaling.
Liongue C, Sertori R, Ward AC. Liongue C, et al. J Immunol. 2016 Jul 1;197(1):11-8. doi: 10.4049/jimmunol.1600372. J Immunol. 2016. PMID: 27317733 Free article. Review.
These secreted factors are produced in response to developmental and/or environmental cues and act via cognate cytokine receptors on target cells, stimulating specific intracellular signaling pathways to facilitate appropriate cellular responses. This review …
These secreted factors are produced in response to developmental and/or environmental cues and act via cognate cytokine receptors on …
Regulation of TGF-beta signaling by Smad7.
Yan X, Liu Z, Chen Y. Yan X, et al. Acta Biochim Biophys Sin (Shanghai). 2009 Apr;41(4):263-72. doi: 10.1093/abbs/gmp018. Acta Biochim Biophys Sin (Shanghai). 2009. PMID: 19352540 Free PMC article. Review.
In the well-understood classical TGF-beta signaling pathway, TGF-beta activates Smad signalling via its two cell surface receptors such as TbetaRII and ALK5/TbetaRI, leading to Smad-mediated transcriptional regulation. ...The signaling of TGF-be …
In the well-understood classical TGF-beta signaling pathway, TGF-beta activates Smad signalling via its two cell surfac …
Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis.
Malemud CJ. Malemud CJ. Int J Mol Sci. 2017 Feb 24;18(3):484. doi: 10.3390/ijms18030484. Int J Mol Sci. 2017. PMID: 28245561 Free PMC article. Review.
These cytokines activate several signal transduction pathways, including the Janus kinase/Signal Transducers and Activators of Transcription (JAK/STAT), Stress-Activated/Mitogen-Activated Protein Kinase (SAPK/MAPK) and phosphatidylinositol-3-kin …
These cytokines activate several signal transduction pathways, including the Janus kinase/Signal Transduc …
TGF-beta Signaling from Receptors to Smads.
Hata A, Chen YG. Hata A, et al. Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9):a022061. doi: 10.1101/cshperspect.a022061. Cold Spring Harb Perspect Biol. 2016. PMID: 27449815 Free PMC article. Review.
The main attribute of the TGF-beta signaling pathway is context-dependence. Depending on the concentration and type of ligand, target tissue, and developmental stage, TGF-beta family members transmit distinct signals. ...More than a decade of studies have rev …
The main attribute of the TGF-beta signaling pathway is context-dependence. Depending on the concentration and type of ligand, …
New insights into TGF-beta/Smad signaling in tissue fibrosis.
Hu HH, Chen DQ, Wang YN, Feng YL, Cao G, Vaziri ND, Zhao YY. Hu HH, et al. Chem Biol Interact. 2018 Aug 25;292:76-83. doi: 10.1016/j.cbi.2018.07.008. Epub 2018 Jul 11. Chem Biol Interact. 2018. PMID: 30017632 Review.
Smad2 and Smad3 are the two major downstream regulator that promote TGF-beta1-mediated tissue fibrosis, while Smad7 serves as a negative feedback regulator of TGF-beta1/Smad pathway thereby protects against TGF-beta1-mediated fibrosis. ...The role of T …
Smad2 and Smad3 are the two major downstream regulator that promote TGF-beta1-mediated tissue fibrosis, while Smad7 serves as a ne
Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation.
Markopoulos GS, Roupakia E, Marcu KB, Kolettas E. Markopoulos GS, et al. Cells. 2019 Sep 25;8(10):1143. doi: 10.3390/cells8101143. Cells. 2019. PMID: 31557902 Free PMC article. Review.
Inflammatory cytokine signaling initiates signaling pathways leading to the activation of master transcription factors (TFs) such as Smads, STAT3, and NF-kappaB. Moreover, the same inflammatory responses also activate EMT-inducing TF (EMT-TF) families …
Inflammatory cytokine signaling initiates signaling pathways leading to the activation of master transcription f …
SOCS proteins: negative regulators of cytokine signaling.
Krebs DL, Hilton DJ. Krebs DL, et al. Stem Cells. 2001;19(5):378-87. doi: 10.1634/stemcells.19-5-378. Stem Cells. 2001. PMID: 11553846 Free article. Review.
Cytokines regulate the growth and differentiation of cells by binding to cell-surface receptors and activating intracellular signal transduction cascades such as the JAK-STAT pathway. Cytokine signaling is negatively regu
Cytokines regulate the growth and differentiation of cells by binding to cell-surface receptors and activating intracellular
The role of JAK/STAT signaling pathway and its inhibitors in diseases.
Xin P, Xu X, Deng C, Liu S, Wang Y, Zhou X, Ma H, Wei D, Sun S. Xin P, et al. Int Immunopharmacol. 2020 Mar;80:106210. doi: 10.1016/j.intimp.2020.106210. Epub 2020 Jan 20. Int Immunopharmacol. 2020. PMID: 31972425 Review.
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. ...In …
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and …
Negative regulation of cytokine signaling pathways.
Yasukawa H, Sasaki A, Yoshimura A. Yasukawa H, et al. Annu Rev Immunol. 2000;18:143-64. doi: 10.1146/annurev.immunol.18.1.143. Annu Rev Immunol. 2000. PMID: 10837055 Review.
The CIS family of proteins (also referred to as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. Most of them appear to be induced after stimulation with several different cytokines, …
The CIS family of proteins (also referred to as the SOCS or SSI family) has been implicated in the regulation of signal tra
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