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Crystal structure of gamma-oxapentamidine complexed with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition.
Nunn CM, Jenkins TC, Neidle S. Nunn CM, et al. Among authors: neidle s. Eur J Biochem. 1994 Dec 15;226(3):953-61. doi: 10.1111/j.1432-1033.1994.00953.x. Eur J Biochem. 1994. PMID: 7813486
The structural details of the complex are discussed and compared with the closely analogous complex with pentamidine bound to the same dodecamer [Edwards, K. J., Jenkins, T. C. & Neidle, S. (1992) Biochemistry 31, 7104-7109]. The amidinium groups of the ligand d …
The structural details of the complex are discussed and compared with the closely analogous complex with pentamidine bound to the same dodec …
Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine.
Nunn CM, Jenkins TC, Neidle S. Nunn CM, et al. Among authors: neidle s. Biochemistry. 1993 Dec 21;32(50):13838-43. doi: 10.1021/bi00213a012. Biochemistry. 1993. PMID: 8268158
The structure provides a rationale for the superior DNA-binding properties of propamidine as compared to pentamidine [cf. Edwards, K. J., Jenkins, T. C. & Neidle, S. (1992) Biochemistry 31, 7104-7109]. This is seen to result from (i) decreased minor groove width …
The structure provides a rationale for the superior DNA-binding properties of propamidine as compared to pentamidine [cf. Edwards, K. J., Je …
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