Neirynck S - Search Results

1

Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice.

Vandenbroucke K, Hans W, Van Huysse J, Neirynck S, Demetter P, Remaut E, Rottiers P, Steidler L. Vandenbroucke K, et al. Among authors: neirynck s. Gastroenterology. 2004 Aug;127(2):502-13. doi: 10.1053/j.gastro.2004.05.020. Gastroenterology. 2004. PMID: 15300583

2

Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10.

Steidler L, Neirynck S, Huyghebaert N, Snoeck V, Vermeire A, Goddeeris B, Cox E, Remon JP, Remaut E. Steidler L, et al. Among authors: neirynck s. Nat Biotechnol. 2003 Jul;21(7):785-9. doi: 10.1038/nbt840. Epub 2003 Jun 15. Nat Biotechnol. 2003. PMID: 12808464

3

Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance.

Termont S, Vandenbroucke K, Iserentant D, Neirynck S, Steidler L, Remaut E, Rottiers P. Termont S, et al. Among authors: neirynck s. Appl Environ Microbiol. 2006 Dec;72(12):7694-700. doi: 10.1128/AEM.01388-06. Epub 2006 Oct 6. Appl Environ Microbiol. 2006. PMID: 17028239 Free PMC article.

4

Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice.

Waeytens A, Ferdinande L, Neirynck S, Rottiers P, De Vos M, Steidler L, Cuvelier CA. Waeytens A, et al. Among authors: neirynck s. Inflamm Bowel Dis. 2008 Apr;14(4):471-9. doi: 10.1002/ibd.20346. Inflamm Bowel Dis. 2008. PMID: 18092343

5

AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis.

Caluwaerts S, Vandenbroucke K, Steidler L, Neirynck S, Vanhoenacker P, Corveleyn S, Watkins B, Sonis S, Coulie B, Rottiers P. Caluwaerts S, et al. Among authors: neirynck s. Oral Oncol. 2010 Jul;46(7):564-70. doi: 10.1016/j.oraloncology.2010.04.008. Epub 2010 Jun 9. Oral Oncol. 2010. PMID: 20542722

6

Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, Fiers W, Remaut E. Steidler L, et al. Among authors: neirynck s. Science. 2000 Aug 25;289(5483):1352-5. doi: 10.1126/science.289.5483.1352. Science. 2000. PMID: 10958782

7

Evaluation of extrusion/spheronisation, layering and compaction for the preparation of an oral, multi-particulate formulation of viable, hIL-10 producing Lactococcus lactis.

Huyghebaert N, Vermeire A, Neirynck S, Steidler L, Remaut E, Remon JP. Huyghebaert N, et al. Among authors: neirynck s. Eur J Pharm Biopharm. 2005 Jan;59(1):9-15. doi: 10.1016/j.ejpb.2004.09.003. Eur J Pharm Biopharm. 2005. PMID: 15567296

8

Development of an enteric-coated formulation containing freeze-dried, viable recombinant Lactococcus lactis for the ileal mucosal delivery of human interleukin-10.

Huyghebaert N, Vermeire A, Neirynck S, Steidler L, Remaut E, Remon JP. Huyghebaert N, et al. Among authors: neirynck s. Eur J Pharm Biopharm. 2005 Aug;60(3):349-59. doi: 10.1016/j.ejpb.2005.02.012. Eur J Pharm Biopharm. 2005. PMID: 15927456

9

Delivery of therapeutic proteins through Lactococcus lactis.

Neirynck S, Steidler L. Neirynck S, et al. Biotechnol Genet Eng Rev. 2006;22:253-66. doi: 10.1080/02648725.2006.10648073. Biotechnol Genet Eng Rev. 2006. PMID: 18476334 Review. No abstract available.

10

A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease.

Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP, van Deventer SJ, Neirynck S, Peppelenbosch MP, Steidler L. Braat H, et al. Among authors: neirynck s. Clin Gastroenterol Hepatol. 2006 Jun;4(6):754-9. doi: 10.1016/j.cgh.2006.03.028. Epub 2006 May 22. Clin Gastroenterol Hepatol. 2006. PMID: 16716759 Clinical Trial.

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