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Characterization of recombinant human IL-15 deamidation and its practical elimination through substitution of asparagine 77.
Nellis DF, Michiel DF, Jiang MS, Esposito D, Davis R, Jiang H, Korrell A, Knapp GC 4th, Lucernoni LE, Nelson RE, Pritt EM, Procter LV, Rogers M, Sumpter TL, Vyas VV, Waybright TJ, Yang X, Zheng AM, Yovandich JL, Gilly JA, Mitra G, Zhu J. Nellis DF, et al. Pharm Res. 2012 Mar;29(3):722-38. doi: 10.1007/s11095-011-0597-0. Epub 2011 Oct 19. Pharm Res. 2012. PMID: 22009587
Dynamics differentiate between active and inactive inteins.
Cronin M, Coolbaugh MJ, Nellis D, Zhu J, Wood DW, Nussinov R, Ma B. Cronin M, et al. Eur J Med Chem. 2015 Feb 16;91:51-62. doi: 10.1016/j.ejmech.2014.07.094. Epub 2014 Jul 27. Eur J Med Chem. 2015. PMID: 25087201 Free PMC article.