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The history of the tetracyclines.
Nelson ML, Levy SB. Nelson ML, et al. Ann N Y Acad Sci. 2011 Dec;1241:17-32. doi: 10.1111/j.1749-6632.2011.06354.x. Ann N Y Acad Sci. 2011. PMID: 22191524 Review.
Anti-inflammatory activity of tetracyclines: applications to human disease.
Higgins PJ, Draper M, Nelson M. Higgins PJ, et al. Antiinflamm Antiallergy Agents Med Chem. 2011;10(2):132-52. Antiinflamm Antiallergy Agents Med Chem. 2011. PMID: 25182060
Brief communication: Mass spectroscopic characterization of tetracycline in the skeletal remains of an ancient population from Sudanese Nubia 350-550 CE.
Nelson ML, Dinardo A, Hochberg J, Armelagos GJ. Nelson ML, et al. Am J Phys Anthropol. 2010 Sep;143(1):151-4. doi: 10.1002/ajpa.21340. Am J Phys Anthropol. 2010. PMID: 20564518
Structure-activity relationship of the aminomethylcyclines and the discovery of omadacycline.
Honeyman L, Ismail M, Nelson ML, Bhatia B, Bowser TE, Chen J, Mechiche R, Ohemeng K, Verma AK, Cannon EP, Macone A, Tanaka SK, Levy S. Honeyman L, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):7044-53. doi: 10.1128/AAC.01536-15. Epub 2015 Sep 8. Antimicrob Agents Chemother. 2015. PMID: 26349824 Free PMC article.
A number of aminomethylcyclines with potent in vitro activity (MIC range of ≤0.06 to 2.0 μg/ml) were identified. These novel tetracyclines were more active against one or more of the resistant strains than the reference antibiotics tested (MIC range, 16 to 64 μg/ml) …
A number of aminomethylcyclines with potent in vitro activity (MIC range of ≤0.06 to 2.0 μg/ml) were identified. These novel tetracyc …
In vitro and in vivo antimalarial efficacies of optimized tetracyclines.
Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. Draper MP, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3131-6. doi: 10.1128/AAC.00451-13. Epub 2013 Apr 29. Antimicrob Agents Chemother. 2013. PMID: 23629719 Free PMC article.
Chemical and biological dynamics of tetracyclines.
Nelson ML. Nelson ML. Adv Dent Res. 1998 Nov;12(2):5-11. doi: 10.1177/08959374980120011901. Adv Dent Res. 1998. PMID: 9972116 Review. No abstract available.
Versatile and facile synthesis of diverse semisynthetic tetracycline derivatives via Pd-catalyzed reactions.
Nelson ML, Ismail MY, McIntyre L, Bhatia B, Viski P, Hawkins P, Rennie G, Andorsky D, Messersmith D, Stapleton K, Dumornay J, Sheahan P, Verma AK, Warchol T, Levy SB. Nelson ML, et al. J Org Chem. 2003 Jul 25;68(15):5838-51. doi: 10.1021/jo030047d. J Org Chem. 2003. PMID: 12868916
Reversal of tetracycline resistance mediated by different bacterial tetracycline resistance determinants by an inhibitor of the Tet(B) antiport protein.
Nelson ML, Levy SB. Nelson ML, et al. Antimicrob Agents Chemother. 1999 Jul;43(7):1719-24. doi: 10.1128/AAC.43.7.1719. Antimicrob Agents Chemother. 1999. PMID: 10390229 Free PMC article.
Nelson, B. H. Park, J. S. Andrews, V. A. Georgian, R. C. Thomas, and S. B. Levy, J. Med. Chem. 36:370-377, 1993). A representative C-13-substituted analog, 13-cyclopentylthio-5-OH-TC (13-CPTC), was shown to competitively inhibit TC translocation by the Tet(B) protein, bloc
Nelson, B. H. Park, J. S. Andrews, V. A. Georgian, R. C. Thomas, and S. B. Levy, J. Med. Chem. 36:370-377, 1993). A representative C-
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