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An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation.
Dufield DR, Nemirovskiy OV, Jennings MG, Tortorella MD, Malfait AM, Mathews WR. Dufield DR, et al. Among authors: nemirovskiy ov. Anal Biochem. 2010 Nov 15;406(2):113-23. doi: 10.1016/j.ab.2010.06.044. Epub 2010 Jul 23. Anal Biochem. 2010. PMID: 20603097
Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes.
Settle S, Vickery L, Nemirovskiy O, Vidmar T, Bendele A, Messing D, Ruminski P, Schnute M, Sunyer T. Settle S, et al. Arthritis Rheum. 2010 Oct;62(10):3006-15. doi: 10.1002/art.27596. Arthritis Rheum. 2010. PMID: 20533541 Free article.
30 results