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Amyloid beta-peptide aggregation. What does it result in and how can it be prevented?
Nerelius C, Johansson J, Sandegren A. Nerelius C, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14:1716-29. doi: 10.2741/3335. Front Biosci (Landmark Ed). 2009. PMID: 19273157
Poly-N-methylated amyloid beta-peptide (Abeta) C-terminal fragments reduce Abeta toxicity in vitro and in Drosophila melanogaster.
Pratim Bose P, Chatterjee U, Nerelius C, Govender T, Norström T, Gogoll A, Sandegren A, Göthelid E, Johansson J, Arvidsson PI. Pratim Bose P, et al. Among authors: nerelius c. J Med Chem. 2009 Dec 24;52(24):8002-9. doi: 10.1021/jm901092h. J Med Chem. 2009. PMID: 19908889
Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.
Kinghorn KJ, Crowther DC, Sharp LK, Nerelius C, Davis RL, Chang HT, Green C, Gubb DC, Johansson J, Lomas DA. Kinghorn KJ, et al. J Biol Chem. 2006 Sep 29;281(39):29268-77. doi: 10.1074/jbc.M600690200. Epub 2006 Jul 17. J Biol Chem. 2006. PMID: 16849336
Amino acid sequence determinants and molecular chaperones in amyloid fibril formation.
Nerelius C, Fitzen M, Johansson J. Nerelius C, et al. Biochem Biophys Res Commun. 2010 May 21;396(1):2-6. doi: 10.1016/j.bbrc.2010.02.105. Biochem Biophys Res Commun. 2010. PMID: 20494101 Review.
Conformational preferences of non-polar amino acid residues: an additional factor in amyloid formation.
Johansson J, Nerelius C, Willander H, Presto J. Johansson J, et al. Among authors: nerelius c. Biochem Biophys Res Commun. 2010 Nov 19;402(3):515-8. doi: 10.1016/j.bbrc.2010.10.062. Epub 2010 Oct 28. Biochem Biophys Res Commun. 2010. PMID: 20971069
Preventing amyloid formation by catching unfolded transmembrane segments.
Johansson H, Nerelius C, Nordling K, Johansson J. Johansson H, et al. Among authors: nerelius c. J Mol Biol. 2009 Jun 5;389(2):227-9. doi: 10.1016/j.jmb.2009.04.021. Epub 2009 Apr 16. J Mol Biol. 2009. PMID: 19376131
Alpha-helix targeting reduces amyloid-beta peptide toxicity.
Nerelius C, Sandegren A, Sargsyan H, Raunak R, Leijonmarck H, Chatterjee U, Fisahn A, Imarisio S, Lomas DA, Crowther DC, Strömberg R, Johansson J. Nerelius C, et al. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9191-6. doi: 10.1073/pnas.0810364106. Epub 2009 May 20. Proc Natl Acad Sci U S A. 2009. PMID: 19458258 Free PMC article.
N-terminal segment of proinsulin C-peptide active in insulin interaction/desaggregation.
Nerelius C, Alvelius G, Jörnvall H. Nerelius C, et al. Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):462-7. doi: 10.1016/j.bbrc.2010.11.058. Epub 2010 Nov 19. Biochem Biophys Res Commun. 2010. PMID: 21094141
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