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The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control.
Nerlov C. Nerlov C. Trends Cell Biol. 2007 Jul;17(7):318-24. doi: 10.1016/j.tcb.2007.07.004. Epub 2007 Jul 19. Trends Cell Biol. 2007. PMID: 17658261 Review.
A main exponent of this phenomenon is the CCAAT/enhancer binding protein (C/EBP) family of basic region-leucine zipper proteins. ...More recently, their position at the crossroads between proliferation and differentiation has made them strong candidate regulators of tumori …
A main exponent of this phenomenon is the CCAAT/enhancer binding protein (C/EBP) family of basic region-leucine zipper proteins. ...M …
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.
Hoppe PS, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Moritz N, Endele M, Filipczyk A, Gambardella A, Ahmed N, Etzrodt M, Coutu DL, Rieger MA, Marr C, Strasser MK, Schauberger B, Burtscher I, Ermakova O, Bürger A, Lickert H, Nerlov C, Theis FJ, Schroeder T. Hoppe PS, et al. Nature. 2016 Jul 14;535(7611):299-302. doi: 10.1038/nature18320. Nature. 2016. PMID: 27411635
FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.
Mancini E, Sanjuan-Pla A, Luciani L, Moore S, Grover A, Zay A, Rasmussen KD, Luc S, Bilbao D, O'Carroll D, Jacobsen SE, Nerlov C. Mancini E, et al. EMBO J. 2012 Jan 18;31(2):351-65. doi: 10.1038/emboj.2011.390. Epub 2011 Nov 8. EMBO J. 2012. PMID: 22068055 Free PMC article.
Finally, C/EBPs and FOG-1 exhibited transcriptional cross-regulation in early myelo-erythroid progenitors making their functional antagonism a potential mechanism for separation of the myeloid and Mk/E lineages....
Finally, C/EBPs and FOG-1 exhibited transcriptional cross-regulation in early myelo-erythroid progenitors making their functional ant …
Targeting a chronic problem: elimination of cancer stem cells in CML.
Nerlov C. Nerlov C. EMBO J. 2009 Feb 4;28(3):167-8. doi: 10.1038/emboj.2008.292. EMBO J. 2009. PMID: 19194482 Free PMC article. No abstract available.
Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.
Kirstetter P, Schuster MB, Bereshchenko O, Moore S, Dvinge H, Kurz E, Theilgaard-Mönch K, Månsson R, Pedersen TA, Pabst T, Schrock E, Porse BT, Jacobsen SE, Bertone P, Tenen DG, Nerlov C. Kirstetter P, et al. Cancer Cell. 2008 Apr;13(4):299-310. doi: 10.1016/j.ccr.2008.02.008. Cancer Cell. 2008. PMID: 18394553
However, p42 was required for control of myeloid progenitor proliferation, and p42-deficient mice developed AML with complete penetrance. p42-deficient leukemia could be transferred by a Mac1+c-Kit+ population that gave rise only to myeloid cells in recipient mice. Express …
However, p42 was required for control of myeloid progenitor proliferation, and p42-deficient mice developed AML with complete penetrance. p4 …
C/EBPs: recipients of extracellular signals through proteome modulation.
Nerlov C. Nerlov C. Curr Opin Cell Biol. 2008 Apr;20(2):180-5. doi: 10.1016/j.ceb.2008.02.002. Epub 2008 Mar 21. Curr Opin Cell Biol. 2008. PMID: 18358708 Review.
Post-translational modification may also control the interaction between C/EBPs and chromatin modifiers, as exemplified by decreased HDAC1-C/EBPbeta interaction upon GCN5-mediated lysine acetylation, and the ability of sumoylation to inhibit C/EBPalpha-SWI/SN …
Post-translational modification may also control the interaction between C/EBPs and chromatin modifiers, as exemplified by decreased …
Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.
Pedersen TA, Bereshchenko O, Garcia-Silva S, Ermakova O, Kurz E, Mandrup S, Porse BT, Nerlov C. Pedersen TA, et al. EMBO J. 2007 Feb 21;26(4):1081-93. doi: 10.1038/sj.emboj.7601563. Epub 2007 Feb 8. EMBO J. 2007. PMID: 17290224 Free PMC article.
Here, we use mouse knock-in mutagenesis to identify C/EBPalpha domains that specifically regulate hepatic gluconeogenesis and lipogenesis. ...These promoters bound SREBP-1 as well as C/EBPalpha, and the PHR was required for C/EBPalpha-SREBP transcriptional sy …
Here, we use mouse knock-in mutagenesis to identify C/EBPalpha domains that specifically regulate hepatic gluconeogenesis and lipogen …
Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.
Calella AM, Nerlov C, Lopez RG, Sciarretta C, von Bohlen und Halbach O, Bereshchenko O, Minichiello L. Calella AM, et al. Neural Dev. 2007 Jan 25;2:4. doi: 10.1186/1749-8104-2-4. Neural Dev. 2007. PMID: 17254333 Free PMC article.
CONCLUSION: We here identify three IE genes as targets for BDNF/TrkB signaling, show that C/EBPalpha and -beta are recruited along with NeuroD to target promoters, and that C/EBPs are essential mediators of Trk signaling in cortical neurons. We show also that C
CONCLUSION: We here identify three IE genes as targets for BDNF/TrkB signaling, show that C/EBPalpha and -beta are recruited along wi …
C/EBPalpha mutations in acute myeloid leukaemias.
Nerlov C. Nerlov C. Nat Rev Cancer. 2004 May;4(5):394-400. doi: 10.1038/nrc1363. Nat Rev Cancer. 2004. PMID: 15122210 Review. No abstract available.
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.
Kirstetter P, Anderson K, Porse BT, Jacobsen SE, Nerlov C. Kirstetter P, et al. Nat Immunol. 2006 Oct;7(10):1048-56. doi: 10.1038/ni1381. Epub 2006 Sep 3. Nat Immunol. 2006. PMID: 16951689
Loss of hematopoietic stem cell function was associated with decreased expression of Cdkn1a (encoding the cell cycle inhibitor p21(cdk)), Sfpi1, Hoxb4 and Bmi1 (encoding the transcription factors PU.1, HoxB4 and Bmi-1, respectively) and altered integrin expression in Lin(-)Sca-1( …
Loss of hematopoietic stem cell function was associated with decreased expression of Cdkn1a (encoding the cell cycle inhibitor p21(cdk)), Sf …
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