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B cells acquire antigen from target cells after synapse formation.
Batista FD, Iber D, Neuberger MS. Batista FD, et al. Among authors: neuberger ms. Nature. 2001 May 24;411(6836):489-94. doi: 10.1038/35078099. Nature. 2001. PMID: 11373683
DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses.
Harris RS, Sheehy AM, Craig HM, Malim MH, Neuberger MS. Harris RS, et al. Among authors: neuberger ms. Nat Immunol. 2003 Jul;4(7):641-3. doi: 10.1038/ni0703-641. Nat Immunol. 2003. PMID: 12830140 No abstract available.
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines.
Cumbers SJ, Williams GT, Davies SL, Grenfell RL, Takeda S, Batista FD, Sale JE, Neuberger MS. Cumbers SJ, et al. Among authors: neuberger ms. Nat Biotechnol. 2002 Nov;20(11):1129-34. doi: 10.1038/nbt752. Epub 2002 Oct 15. Nat Biotechnol. 2002. PMID: 12379869
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.
Di Noia J, Neuberger MS. Di Noia J, et al. Among authors: neuberger ms. Nature. 2002 Sep 5;419(6902):43-8. doi: 10.1038/nature00981. Epub 2002 Jul 31. Nature. 2002. PMID: 12214226
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.
Petersen-Mahrt SK, Harris RS, Neuberger MS. Petersen-Mahrt SK, et al. Among authors: neuberger ms. Nature. 2002 Jul 4;418(6893):99-103. doi: 10.1038/nature00862. Nature. 2002. PMID: 12097915
Interaction of CD22 with alpha2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity?
Lanoue A, Batista FD, Stewart M, Neuberger MS. Lanoue A, et al. Among authors: neuberger ms. Eur J Immunol. 2002 Feb;32(2):348-55. doi: 10.1002/1521-4141(200202)32:2<348::AID-IMMU348>3.0.CO;2-5. Eur J Immunol. 2002. PMID: 11807774
AID is essential for immunoglobulin V gene conversion in a cultured B cell line.
Harris RS, Sale JE, Petersen-Mahrt SK, Neuberger MS. Harris RS, et al. Among authors: neuberger ms. Curr Biol. 2002 Mar 5;12(5):435-8. doi: 10.1016/s0960-9822(02)00717-0. Curr Biol. 2002. PMID: 11882297
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity.
Wang M, Yang Z, Rada C, Neuberger MS. Wang M, et al. Among authors: neuberger ms. Nat Struct Mol Biol. 2009 Jul;16(7):769-76. doi: 10.1038/nsmb.1623. Epub 2009 Jun 21. Nat Struct Mol Biol. 2009. PMID: 19543289 Free PMC article.
Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.
Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C. Neuberger MS, et al. Nat Rev Immunol. 2005 Feb;5(2):171-8. doi: 10.1038/nri1553. Nat Rev Immunol. 2005. PMID: 15688043 Review.
Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells.
Harris RS, Croom-Carter DS, Rickinson AB, Neuberger MS. Harris RS, et al. Among authors: neuberger ms. J Virol. 2001 Nov;75(21):10488-92. doi: 10.1128/JVI.75.21.10488-10492.2001. J Virol. 2001. PMID: 11581418 Free PMC article.
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