Neuhoff S - Search Results

1

A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporine.

Jamei M, Bajot F, Neuhoff S, Barter Z, Yang J, Rostami-Hodjegan A, Rowland-Yeo K. Jamei M, et al. Among authors: neuhoff s. Clin Pharmacokinet. 2014 Jan;53(1):73-87. doi: 10.1007/s40262-013-0097-y. Clin Pharmacokinet. 2014. PMID: 23881596 Free PMC article.

2

Population-based mechanistic prediction of oral drug absorption.

Jamei M, Turner D, Yang J, Neuhoff S, Polak S, Rostami-Hodjegan A, Tucker G. Jamei M, et al. Among authors: neuhoff s. AAPS J. 2009 Jun;11(2):225-37. doi: 10.1208/s12248-009-9099-y. Epub 2009 Apr 21. AAPS J. 2009. PMID: 19381840 Free PMC article. Review.

3

Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model.

Darwich AS, Neuhoff S, Jamei M, Rostami-Hodjegan A. Darwich AS, et al. Among authors: neuhoff s. Curr Drug Metab. 2010 Nov;11(9):716-29. doi: 10.2174/138920010794328913. Curr Drug Metab. 2010. PMID: 21189140

4

Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption.

Harwood MD, Neuhoff S, Carlson GL, Warhurst G, Rostami-Hodjegan A. Harwood MD, et al. Among authors: neuhoff s. Biopharm Drug Dispos. 2013 Jan;34(1):2-28. doi: 10.1002/bdd.1810. Epub 2012 Oct 8. Biopharm Drug Dispos. 2013. PMID: 22927116 Review.

5

Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.

Bentz J, O'Connor MP, Bednarczyk D, Coleman J, Lee C, Palm J, Pak YA, Perloff ES, Reyner E, Balimane P, Brännström M, Chu X, Funk C, Guo A, Hanna I, Herédi-Szabó K, Hillgren K, Li L, Hollnack-Pusch E, Jamei M, Lin X, Mason AK, Neuhoff S, Patel A, Podila L, Plise E, Rajaraman G, Salphati L, Sands E, Taub ME, Taur JS, Weitz D, Wortelboer HM, Xia CQ, Xiao G, Yabut J, Yamagata T, Zhang L, Ellens H. Bentz J, et al. Among authors: neuhoff s. Drug Metab Dispos. 2013 Jul;41(7):1347-66. doi: 10.1124/dmd.112.050500. Epub 2013 Apr 25. Drug Metab Dispos. 2013. PMID: 23620485 Free PMC article.

6

Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.

Neuhoff S, Yeo KR, Barter Z, Jamei M, Turner DB, Rostami-Hodjegan A. Neuhoff S, et al. J Pharm Sci. 2013 Sep;102(9):3161-73. doi: 10.1002/jps.23607. Epub 2013 May 19. J Pharm Sci. 2013. PMID: 23686764

7

Application of permeability-limited physiologically-based pharmacokinetic models: part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux.

Neuhoff S, Yeo KR, Barter Z, Jamei M, Turner DB, Rostami-Hodjegan A. Neuhoff S, et al. J Pharm Sci. 2013 Sep;102(9):3145-60. doi: 10.1002/jps.23594. Epub 2013 May 22. J Pharm Sci. 2013. PMID: 23703021

8

Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin.

Rose RH, Neuhoff S, Abduljalil K, Chetty M, Rostami-Hodjegan A, Jamei M. Rose RH, et al. Among authors: neuhoff s. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 9;3(7):e124. doi: 10.1038/psp.2014.24. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25006781 Free PMC article.

9

Lost in centrifugation: accounting for transporter protein losses in quantitative targeted absolute proteomics.

Harwood MD, Russell MR, Neuhoff S, Warhurst G, Rostami-Hodjegan A. Harwood MD, et al. Among authors: neuhoff s. Drug Metab Dispos. 2014 Oct;42(10):1766-72. doi: 10.1124/dmd.114.058446. Epub 2014 Jul 24. Drug Metab Dispos. 2014. PMID: 25061159

10

In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition.

Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G, Rostami-Hodjegan A. Harwood MD, et al. Among authors: neuhoff s. Drug Metab Dispos. 2016 Mar;44(3):476-80. doi: 10.1124/dmd.115.067777. Epub 2016 Feb 3. Drug Metab Dispos. 2016. PMID: 26842595

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