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1993 2
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2007 1
2012 1
2013 1
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2019 1
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Page 1
Progressive multiple sclerosis: pathology and pathogenesis.
Lassmann H, van Horssen J, Mahad D. Lassmann H, et al. Nat Rev Neurol. 2012 Nov 5;8(11):647-56. doi: 10.1038/nrneurol.2012.168. Epub 2012 Sep 25. Nat Rev Neurol. 2012. PMID: 23007702 Review.
In progressive MS, as in relapsing-remitting MS, active tissue injury is associated with inflammation, but the inflammatory response in the progressive phase occurs at least partly behind the blood-brain barrier, which makes it more difficult to treat. The other mechanisms …
In progressive MS, as in relapsing-remitting MS, active tissue injury is associated with inflammation, but the inflammatory response in the …
Iron in multiple sclerosis: roles in neurodegeneration and repair.
Stephenson E, Nathoo N, Mahjoub Y, Dunn JF, Yong VW. Stephenson E, et al. Nat Rev Neurol. 2014 Aug;10(8):459-68. doi: 10.1038/nrneurol.2014.118. Epub 2014 Jul 8. Nat Rev Neurol. 2014. PMID: 25002107 Review.
MRI and histological studies have shown global alterations in iron levels in the brains of patients with multiple sclerosis (MS), including increases in the iron stored by macrophages and microglia. Excessive free iron can be toxic, and accumulation
MRI and histological studies have shown global alterations in iron levels in the brains of patients with multiple sclerosis (M …
Pathophysiology and Neuroimmune Interactions Underlying Parkinson's Disease and Traumatic Brain Injury.
Lillian A, Zuo W, Laham L, Hilfiker S, Ye JH. Lillian A, et al. Int J Mol Sci. 2023 Apr 13;24(8):7186. doi: 10.3390/ijms24087186. Int J Mol Sci. 2023. PMID: 37108349 Free PMC article. Review.
Traumatic brain injury (TBI) has been implicated as a risk factor for developing various neurodegenerative diseases, with the most compelling argument for the development of PD. ...Neuronal iron accumulation is discernable in degenerative and injured brain
Traumatic brain injury (TBI) has been implicated as a risk factor for developing various neurodegenerative diseases, with the most co …
Iron in neurodegenerative disorders: being in the wrong place at the wrong time?
Apostolakis S, Kypraiou AM. Apostolakis S, et al. Rev Neurosci. 2017 Nov 27;28(8):893-911. doi: 10.1515/revneuro-2017-0020. Rev Neurosci. 2017. PMID: 28792913 Review.
Brain iron deposits have been reported consistently in imaging and histologic examinations of patients with neurodegenerative disorders. ...Understanding the underlying processes of iron metabolism in the brain and particularly its release during cell
Brain iron deposits have been reported consistently in imaging and histologic examinations of patients with neurodegenerative
Iron metabolism in the CNS: implications for neurodegenerative diseases.
Rouault TA. Rouault TA. Nat Rev Neurosci. 2013 Aug;14(8):551-64. doi: 10.1038/nrn3453. Epub 2013 Jul 3. Nat Rev Neurosci. 2013. PMID: 23820773 Review.
Abnormal accumulation of brain iron has been detected in various neurodegenerative diseases, but the contribution of iron overload to pathology remains unclear. In a group of distinctive brain iron overload diseases known as 'neurodege
Abnormal accumulation of brain iron has been detected in various neurodegenerative diseases, but the contribution of …
A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer's and Parkinson's diseases.
Singh YP, Pandey A, Vishwakarma S, Modi G. Singh YP, et al. Mol Divers. 2019 May;23(2):509-526. doi: 10.1007/s11030-018-9878-4. Epub 2018 Oct 6. Mol Divers. 2019. PMID: 30293116 Review.
Iron concentration increases in the brain with age due to multiple factors. ...There is an urgent need of novel therapies which should not only provide symptomatic relief but also be able to modulate iron accumulation in the brain. Therefore, th
Iron concentration increases in the brain with age due to multiple factors. ...There is an urgent need of novel therapies whic
A matter of concern - Trace element dyshomeostasis and genomic stability in neurons.
Wandt VK, Winkelbeiner N, Bornhorst J, Witt B, Raschke S, Simon L, Ebert F, Kipp AP, Schwerdtle T. Wandt VK, et al. Redox Biol. 2021 May;41:101877. doi: 10.1016/j.redox.2021.101877. Epub 2021 Jan 24. Redox Biol. 2021. PMID: 33607499 Free PMC article. Review.
Neurons are post-mitotic cells in the brain and their integrity is of central importance to avoid neurodegeneration. ...In this context, imbalances in brain trace element homeostasis are a matter of concern, especially regarding iron, copper, manganese …
Neurons are post-mitotic cells in the brain and their integrity is of central importance to avoid neurodegeneration. ...In thi …
The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models.
Amit T, Bar-Am O, Mechlovich D, Kupershmidt L, Youdim MBH, Weinreb O. Amit T, et al. Neuropharmacology. 2017 Sep 1;123:359-367. doi: 10.1016/j.neuropharm.2017.05.026. Epub 2017 May 29. Neuropharmacology. 2017. PMID: 28571715 Review.
In many of the neurodegenerative diseases, such as Alzheimer's disease (AD) and AD-related disorders, as well as in the regular ageing process, excessive generation of oxidative stress (OS) and accumulation of iron levels and deposition have been observed in specifi …
In many of the neurodegenerative diseases, such as Alzheimer's disease (AD) and AD-related disorders, as well as in the regular ageing proce …
The possible role of iron in the etiopathology of Parkinson's disease.
Youdim MB, Ben-Shachar D, Riederer P. Youdim MB, et al. Mov Disord. 1993;8(1):1-12. doi: 10.1002/mds.870080102. Mov Disord. 1993. PMID: 8419792 Review.
However, the recently described pathology of PD supports the view for a state of oxidative stress in the substantia nigra (SN), resulting as a consequence of the selective accumulation of iron in SN zona compacta and within the melanized dopamine neurons. ...These i …
However, the recently described pathology of PD supports the view for a state of oxidative stress in the substantia nigra (SN), resulting as …
The redox chemistry of the Alzheimer's disease amyloid beta peptide.
Smith DG, Cappai R, Barnham KJ. Smith DG, et al. Biochim Biophys Acta. 2007 Aug;1768(8):1976-90. doi: 10.1016/j.bbamem.2007.02.002. Epub 2007 Feb 9. Biochim Biophys Acta. 2007. PMID: 17433250 Free article. Review.
With normal ageing the brain accumulates metals ions such iron (Fe), zinc (Zn) and copper (Cu). ...In AD there is an over accumulation of the Amyloid beta peptide (Abeta), this is the result of either an elevated generation from amyloid precursor prote …
With normal ageing the brain accumulates metals ions such iron (Fe), zinc (Zn) and copper (Cu). ...In AD there is an ov …
13 results