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1986 1
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2004 5
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257 results

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Page 1
Neurodegeneration with brain iron accumulation.
Hayflick SJ, Kurian MA, Hogarth P. Hayflick SJ, et al. Handb Clin Neurol. 2018;147:293-305. doi: 10.1016/B978-0-444-63233-3.00019-1. Handb Clin Neurol. 2018. PMID: 29325618 Free PMC article. Review.
Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and genetically heterogeneous group of disorders affecting children and adults. These rare disorders are often first suspected when increased basal ganglia iron is obse
Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and genetically heterogeneous group
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Stockwell BR, et al. Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Cell. 2017. PMID: 28985560 Free PMC article. Review.
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. ...Ferroptosis has been implicated in the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Hunti …
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to leth …
Cerebral Iron Deposition in Neurodegeneration.
Dusek P, Hofer T, Alexander J, Roos PM, Aaseth JO. Dusek P, et al. Biomolecules. 2022 May 17;12(5):714. doi: 10.3390/biom12050714. Biomolecules. 2022. PMID: 35625641 Free PMC article. Review.
On the microscopic level, brain iron deposits are present mostly in dystrophic microglia variably accompanied by iron-laden macrophages and in astrocytes, implicating a role of inflammatory changes and blood-brain barrier disturbance in iron
On the microscopic level, brain iron deposits are present mostly in dystrophic microglia variably accompanied by iron-l …
Wilson's disease: update on pathogenesis, biomarkers and treatments.
Shribman S, Poujois A, Bandmann O, Czlonkowska A, Warner TT. Shribman S, et al. J Neurol Neurosurg Psychiatry. 2021 Oct;92(10):1053-1061. doi: 10.1136/jnnp-2021-326123. Epub 2021 Aug 2. J Neurol Neurosurg Psychiatry. 2021. PMID: 34341141 Review.
The genetic and molecular mechanisms associated with ATP7B dysfunction have been well characterised, but despite extensive efforts to identify genotype-phenotype correlations, the reason why only some patients develop neurological or psychiatric features remains unclear. We discu …
The genetic and molecular mechanisms associated with ATP7B dysfunction have been well characterised, but despite extensive efforts to identi …
Neurodegeneration with brain iron accumulation.
Wiethoff S, Houlden H. Wiethoff S, et al. Handb Clin Neurol. 2017;145:157-166. doi: 10.1016/B978-0-12-802395-2.00011-0. Handb Clin Neurol. 2017. PMID: 28987166 Review.
Neurodegeneration with brain iron accumulation (NBIA) describes a heterogeneous group of inherited rare clinical and genetic entities. ...Neuropathologically, NBIA disorders usually are associated with widespread axonal spheroids and local iron
Neurodegeneration with brain iron accumulation (NBIA) describes a heterogeneous group of inherited rare clinical
Progressive multiple sclerosis: pathology and pathogenesis.
Lassmann H, van Horssen J, Mahad D. Lassmann H, et al. Nat Rev Neurol. 2012 Nov 5;8(11):647-56. doi: 10.1038/nrneurol.2012.168. Epub 2012 Sep 25. Nat Rev Neurol. 2012. PMID: 23007702 Review.
In progressive MS, as in relapsing-remitting MS, active tissue injury is associated with inflammation, but the inflammatory response in the progressive phase occurs at least partly behind the blood-brain barrier, which makes it more difficult to treat. The other mechanisms …
In progressive MS, as in relapsing-remitting MS, active tissue injury is associated with inflammation, but the inflammatory response in the …
The role of iron in brain ageing and neurodegenerative disorders.
Ward RJ, Zucca FA, Duyn JH, Crichton RR, Zecca L. Ward RJ, et al. Lancet Neurol. 2014 Oct;13(10):1045-60. doi: 10.1016/S1474-4422(14)70117-6. Lancet Neurol. 2014. PMID: 25231526 Free PMC article. Review.
During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. ...MRI can often identify these changes, thus providing a potential diagnostic biomarker of neurodegenerative diseases. An important avenue to …
During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. ... …
Neurodegeneration with Brain Iron Accumulation.
Schneider SA. Schneider SA. Curr Neurol Neurosci Rep. 2016 Jan;16(1):9. doi: 10.1007/s11910-015-0608-3. Curr Neurol Neurosci Rep. 2016. PMID: 26739693 Review.
Syndromes with neurodegeneration with brain iron accumulation (NBIA) are a group of neurodegenerative disorders characterized by abnormalities in brain iron metabolism with excess iron accumulation in the globus pallidus and …
Syndromes with neurodegeneration with brain iron accumulation (NBIA) are a group of neurodegenerative disorders …
WDR45, one gene associated with multiple neurodevelopmental disorders.
Cong Y, So V, Tijssen MAJ, Verbeek DS, Reggiori F, Mauthe M. Cong Y, et al. Autophagy. 2021 Dec;17(12):3908-3923. doi: 10.1080/15548627.2021.1899669. Epub 2021 Apr 12. Autophagy. 2021. PMID: 33843443 Free PMC article. Review.
The precise cellular function of WDR45 is still largely unknown, but deletions or conventional variants in WDR45 can lead to macroautophagy/autophagy defects, malfunctioning mitochondria, endoplasmic reticulum stress and unbalanced iron homeostasis, suggesting that this pr …
The precise cellular function of WDR45 is still largely unknown, but deletions or conventional variants in WDR45 can lead to macroautophagy/ …
Astrocytes in heavy metal neurotoxicity and neurodegeneration.
Li B, Xia M, Zorec R, Parpura V, Verkhratsky A. Li B, et al. Brain Res. 2021 Feb 1;1752:147234. doi: 10.1016/j.brainres.2020.147234. Epub 2021 Jan 5. Brain Res. 2021. PMID: 33412145 Free PMC article. Review.
In particular, we focus on astroglial mechanisms of iron-induced neurotoxicity. Iron deposits in the brain are detected in main neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Accumulation
In particular, we focus on astroglial mechanisms of iron-induced neurotoxicity. Iron deposits in the brain are detected …
257 results