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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 2
1980 1
1981 1
1982 2
1984 2
1985 3
1986 4
1987 5
1988 8
1989 20
1990 15
1991 31
1992 33
1993 27
1994 41
1995 28
1996 64
1997 46
1998 49
1999 45
2000 53
2001 40
2002 77
2003 66
2004 76
2005 82
2006 114
2007 73
2008 68
2009 84
2010 110
2011 101
2012 79
2013 97
2014 105
2015 103
2016 120
2017 125
2018 109
2019 131
2020 149
2021 172
2022 136
2023 123
2024 30

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2,602 results

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Page 1
The neuropathological diagnosis of Alzheimer's disease.
DeTure MA, Dickson DW. DeTure MA, et al. Mol Neurodegener. 2019 Aug 2;14(1):32. doi: 10.1186/s13024-019-0333-5. Mol Neurodegener. 2019. PMID: 31375134 Free PMC article. Review.
The cardinal pathological features of the disease have been known for more than one hundred years, and today the presence of these amyloid plaques and neurofibrillary tangles are still required for a pathological diagnosis. ...
The cardinal pathological features of the disease have been known for more than one hundred years, and today the presence of these amyloid p …
Neuropathological stageing of Alzheimer-related changes.
Braak H, Braak E. Braak H, et al. Acta Neuropathol. 1991;82(4):239-59. doi: 10.1007/BF00308809. Acta Neuropathol. 1991. PMID: 1759558 Review.
Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The distribution of neuritic plaques varied widely not only within architectonic units but also from one individual to another. Neurofibrillary
Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The dis
Neuropathological alterations in Alzheimer disease.
Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Serrano-Pozo A, et al. Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189. doi: 10.1101/cshperspect.a006189. Cold Spring Harb Perspect Med. 2011. PMID: 22229116 Free PMC article. Review.
The neuropathological hallmarks of Alzheimer disease (AD) include "positive" lesions such as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial responses, and "negative" lesions such as neuronal and synaptic loss. ...In addition, cli …
The neuropathological hallmarks of Alzheimer disease (AD) include "positive" lesions such as amyloid plaques and cerebral amyloid angiopathy …
Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis.
Bloom GS. Bloom GS. JAMA Neurol. 2014 Apr;71(4):505-8. doi: 10.1001/jamaneurol.2013.5847. JAMA Neurol. 2014. PMID: 24493463 Review.
The AD brain is characterized microscopically by the combined presence of 2 classes of abnormal structures, extracellular amyloid plaques and intraneuronal neurofibrillary tangles, both of which comprise highly insoluble, densely packed filaments. ...The behavioral …
The AD brain is characterized microscopically by the combined presence of 2 classes of abnormal structures, extracellular amyloid plaques an …
Neuropathology of Alzheimer's Disease.
Trejo-Lopez JA, Yachnis AT, Prokop S. Trejo-Lopez JA, et al. Neurotherapeutics. 2022 Jan;19(1):173-185. doi: 10.1007/s13311-021-01146-y. Epub 2021 Nov 2. Neurotherapeutics. 2022. PMID: 34729690 Free PMC article. Review.
The key pathological hallmarks-extracellular plaques and intracellular neurofibrillary tangles (NFT)-described by Alois Alzheimer in his seminal 1907 article are still central to the postmortem diagnosis of Alzheimer's disease (AD), but major advances in our underst …
The key pathological hallmarks-extracellular plaques and intracellular neurofibrillary tangles (NFT)-described by Alois Alzhei …
Insights into Alzheimer's disease from single-cell genomic approaches.
Murdock MH, Tsai LH. Murdock MH, et al. Nat Neurosci. 2023 Feb;26(2):181-195. doi: 10.1038/s41593-022-01222-2. Epub 2023 Jan 2. Nat Neurosci. 2023. PMID: 36593328 Free PMC article. Review.
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling has shown that Alzheimer's dementia involves the complex interplay of virtually …
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics.
Karran E, De Strooper B. Karran E, et al. Nat Rev Drug Discov. 2022 Apr;21(4):306-318. doi: 10.1038/s41573-022-00391-w. Epub 2022 Feb 17. Nat Rev Drug Discov. 2022. PMID: 35177833 Review.
With the aim of informing this debate, we review clinical trial data for drugs that target Abeta from the perspective of the temporal interplay between the two pathognomonic protein aggregates in AD - Abeta plaques and tau neurofibrillary tangles - and their relatio …
With the aim of informing this debate, we review clinical trial data for drugs that target Abeta from the perspective of the temporal interp …
Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation.
Ashrafian H, Zadeh EH, Khan RH. Ashrafian H, et al. Int J Biol Macromol. 2021 Jan 15;167:382-394. doi: 10.1016/j.ijbiomac.2020.11.192. Epub 2020 Dec 2. Int J Biol Macromol. 2021. PMID: 33278431 Review.
Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Abeta) outside of neuron cells and tau aggregation or neurofibrillary tangles (NFTs) formation inside the cell may play crucial roles. ...
Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Abeta) outside of neuron cell …
Alzheimer's disease.
Querfurth HW, LaFerla FM. Querfurth HW, et al. N Engl J Med. 2010 Jan 28;362(4):329-44. doi: 10.1056/NEJMra0909142. N Engl J Med. 2010. PMID: 20107219 Free article. Review. No abstract available.
Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies.
Gao Y, Tan L, Yu JT, Tan L. Gao Y, et al. Curr Alzheimer Res. 2018;15(3):283-300. doi: 10.2174/1567205014666170417111859. Curr Alzheimer Res. 2018. PMID: 28413986 Review.
The hyperphosphorylation and abnormal aggregation of tau, combined with its decreased clearance, form neurofibrillary tangles (NFTs) and exert neurotoxicity in AD. METHODS: Recent investigations aim to prevent the deposition of NFT and accelerate the clearance of NF …
The hyperphosphorylation and abnormal aggregation of tau, combined with its decreased clearance, form neurofibrillary tangles
2,602 results