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Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells.
Jeon I, Lee N, Li JY, Park IH, Park KS, Moon J, Shim SH, Choi C, Chang DJ, Kwon J, Oh SH, Shin DA, Kim HS, Do JT, Lee DR, Kim M, Kang KS, Daley GQ, Brundin P, Song J. Jeon I, et al. Stem Cells. 2012 Sep;30(9):2054-62. doi: 10.1002/stem.1135. Stem Cells. 2012. PMID: 22628015 Free article.
Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can be used to model different human diseases. They may also serve as sources of transplantable cells that can be used in novel cell therapies. Here, we analy
Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can be used to model diff
Cysteamine Protects Neurons from Mutant Huntingtin Toxicity.
Arbez N, Roby E, Akimov S, Eddings C, Ren M, Wang X, Ross CA. Arbez N, et al. J Huntingtons Dis. 2019;8(2):129-143. doi: 10.3233/JHD-180312. J Huntingtons Dis. 2019. PMID: 30856117 Free PMC article.
BACKGROUND: The potential benefit of cysteamine for Huntington's disease has been demonstrated in HD animal models. Cysteamine and its derivate cystamine were shown to reduce neuropathology and prolong lifespan. ...Cysteamine also rescued mitochondrial change …
BACKGROUND: The potential benefit of cysteamine for Huntington's disease has been demonstrated in HD animal models. Cys …