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Neuronal Activation Stimulates Cytomegalovirus Promoter-Driven Transgene Expression.
Bäck S, Dossat A, Parkkinen I, Koivula P, Airavaara M, Richie CT, Chen YH, Wang Y, Harvey BK. Bäck S, et al. Mol Ther Methods Clin Dev. 2019 Jul 3;14:180-188. doi: 10.1016/j.omtm.2019.06.006. eCollection 2019 Sep 13. Mol Ther Methods Clin Dev. 2019. PMID: 31380464 Free PMC article.
The CMV promoter has long been considered a stable, constitutive, and ubiquitous promoter for transgene expression. ...In contrast, promoters derived from human synapsin 1 (hSYN1) gene or elongation factor 1alpha (EF1alpha) did not exhibit alter …
The CMV promoter has long been considered a stable, constitutive, and ubiquitous promoter for transgene expression
Baroreceptor reflex stimulation does not induce cytomegalovirus promoter-driven transgene expression in the ventrolateral medulla in vivo.
Allen AM, Dosanjh J, Dassanayake S, Tan G, Thomas WG. Allen AM, et al. Auton Neurosci. 2006 Jun 30;126-127:150-5. doi: 10.1016/j.autneu.2006.02.024. Epub 2006 Apr 19. Auton Neurosci. 2006. PMID: 16624635
However, using this promoter, expression in neurons is variable, with strongest expression being observed in non-neuronal cells. ...Prior to stimulation, transgene expression occurs in non-neuronal cells in the RVLM. …
However, using this promoter, expression in neurons is variable, with strongest expression being observed in non …