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Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.
Mar PL, Raj SR. Mar PL, et al. Annu Rev Med. 2020 Jan 27;71:235-248. doi: 10.1146/annurev-med-041818-011630. Epub 2019 Aug 14. Annu Rev Med. 2020. PMID: 31412221 Review.
Patients often will exhibit overlapping characteristics from more than one of these mechanisms. The approach to the treatment of POTS centers on treating the underlying pathophysiologic mechanism. Stockings, abdominal binders, and vasoconstrictors are used to enhance venou …
Patients often will exhibit overlapping characteristics from more than one of these mechanisms. The approach to the treatment of POTS …
Pathophysiology and management of postural orthostatic tachycardia syndrome (POTS): A literature review.
Ghazal M, Akkawi AR, Fancher A, Oundo E, Tanzeem H, Sajjad L, Briasoulis A. Ghazal M, et al. Curr Probl Cardiol. 2025 Mar;50(3):102977. doi: 10.1016/j.cpcardiol.2024.102977. Epub 2024 Dec 18. Curr Probl Cardiol. 2025. PMID: 39706392 Review.
Recent studies have identified three primary POTS phenotypes-hyperadrenergic, neuropathic, and hypovolemic-each requiring tailored management strategies. ...Neuropathic POTS, resulting from impaired vasoconstriction during orthostatic stress, responds …
Recent studies have identified three primary POTS phenotypes-hyperadrenergic, neuropathic, and hypovolemic-each requiring tail …
Hypermobile Ehlers-Danlos Syndrome: Cerebrovascular, Autonomic and Neuropathic Features.
Novak P, Systrom DM, Marciano SP, Witte A, Warren A, Felsenstein D, Giannetti MP, Hamilton MJ, Nicoloro-SantaBarbara J, Castells M, Farhad K, Pilgrim DM, Mullally WJ, Fishman MC, Milunsky JM, Milunsky A, Krier J. Novak P, et al. Am J Med Open. 2025 Jul 18;14:100111. doi: 10.1016/j.ajmo.2025.100111. eCollection 2025 Dec. Am J Med Open. 2025. PMID: 40843452 Free PMC article.
The objective of this study was to describe cerebrovascular, autonomic, and neuropathic features of hEDS. METHODS: This retrospective case-control study was conducted at Brigham and Women's Faulkner Hospital between 2016-2023. ...Outcome measures include validated surveys …
The objective of this study was to describe cerebrovascular, autonomic, and neuropathic features of hEDS. METHODS: This retrospective …
Evaluation of postural tachycardia syndrome (POTS).
Goodman BP. Goodman BP. Auton Neurosci. 2018 Dec;215:12-19. doi: 10.1016/j.autneu.2018.04.004. Epub 2018 Apr 22. Auton Neurosci. 2018. PMID: 29705015 Review.
The diagnostic evaluation of a patient with suspected postural tachycardia syndrome (POTS) requires a thoughtful diagnostic approach utilizing a careful clinical history and examination, laboratory, and autonomic testing. ...The purpose of autonomic testing is to confirm a …
The diagnostic evaluation of a patient with suspected postural tachycardia syndrome (POTS) requires a thoughtful diagnostic approach …
Use of Ivabradine in the Treatment of Patients with Postural Orthostatic Tachycardia Syndrome (POTS): A Systematic Review.
Melo APG, Moretti MA, Chagas ACP. Melo APG, et al. Arq Bras Cardiol. 2025 Nov;122(11):e20250347. doi: 10.36660/abc.20250347. Arq Bras Cardiol. 2025. PMID: 41538594 Free PMC article. English, Portuguese.
There are three phenotypes of POTS - neuropathic, hypovolemic, and hyperadrenergic - and all result in tachycardia and altered cerebral perfusion. ...There are three phenotypes of POTS - neuropathic, hypovolemic, and hyperadrenergic - and all result in …
There are three phenotypes of POTS - neuropathic, hypovolemic, and hyperadrenergic - and all result in tachycardia and altered …
Symptoms and objective signs of peripheral sensory neuropathy in POTS and correlations to gastrointestinal symptoms.
Ekman L, Tufvesson H, Englund E, Dahlin LB, Ohlsson B. Ekman L, et al. PLoS One. 2025 Jul 3;20(7):e0327549. doi: 10.1371/journal.pone.0327549. eCollection 2025. PLoS One. 2025. PMID: 40608783 Free PMC article.
The patients were classified as "High NSS" and "High IBS-SSS" if their total NSS vs. IBS-SSS were above median levels in POTS. RESULTS: Peripheral sensory and gastrointestinal symptoms were more prevalent and severe in POTS than in controls. ...Neuropathic an …
The patients were classified as "High NSS" and "High IBS-SSS" if their total NSS vs. IBS-SSS were above median levels in POTS. RESULT …
Vagal and Sympathetic Function in Neuropathic Postural Tachycardia Syndrome.
Jacob G, Diedrich L, Sato K, Brychta RJ, Raj SR, Robertson D, Biaggioni I, Diedrich A. Jacob G, et al. Hypertension. 2019 May;73(5):1087-1096. doi: 10.1161/HYPERTENSIONAHA.118.11803. Hypertension. 2019. PMID: 30879357 Free PMC article.
The diagnosis of neuropathic postural tachycardia syndrome (POTS) requires research techniques not available clinically. We hypothesized that these patients will have impaired vagal and sympathetic cardiovascular control that can be characterized with clinical auton …
The diagnosis of neuropathic postural tachycardia syndrome (POTS) requires research techniques not available clinically. We hy …
Orthostatic intolerance with tachycardia (postural tachycardia syndrome) and without (hypocapnic cerebral hypoperfusion) represent a spectrum of the same disorder.
Novak P, Systrom DM, Witte A, Marciano SP. Novak P, et al. Front Neurol. 2024 Oct 30;15:1476918. doi: 10.3389/fneur.2024.1476918. eCollection 2024. Front Neurol. 2024. PMID: 39544990 Free PMC article.
This study compared autonomic, cerebrovascular, and neuropathic features of POTS and HYCH. METHODS: This retrospective study evaluated patients with orthostatic intolerance referred for autonomic testing. ...These findings provide additional evidence that HYCH and …
This study compared autonomic, cerebrovascular, and neuropathic features of POTS and HYCH. METHODS: This retrospective study e …
Gastrointestinal symptoms in postural tachycardia syndrome: a systematic review.
Mehr SE, Barbul A, Shibao CA. Mehr SE, et al. Clin Auton Res. 2018 Aug;28(4):411-421. doi: 10.1007/s10286-018-0519-x. Epub 2018 Mar 16. Clin Auton Res. 2018. PMID: 29549458 Free PMC article.
The pathophysiology of gastrointestinal symptoms in POTS is likely multifactorial and probably depends on the co-morbid conditions. In patients with POTS and Ehlers-Danlos syndromes, structural and functional abnormalities in the gastrointestinal connective tissue m …
The pathophysiology of gastrointestinal symptoms in POTS is likely multifactorial and probably depends on the co-morbid conditions. I …
Postural Orthostatic Tachycardia Syndrome: Prevalence, Pathophysiology, and Management.
Zadourian A, Doherty TA, Swiatkiewicz I, Taub PR. Zadourian A, et al. Drugs. 2018 Jul;78(10):983-994. doi: 10.1007/s40265-018-0931-5. Drugs. 2018. PMID: 29943373 Review.
In this review, a comprehensive framework is provided to aid in helping identify and treat patients with POTS. Given its heterogenous nature, it is crucial to understand each component of POTS in relation to one another instead of distinct parts. The framework highl …
In this review, a comprehensive framework is provided to aid in helping identify and treat patients with POTS. Given its heterogenous …
53 results