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Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.
Tornio A, Filppula AM, Kailari O, Neuvonen M, Nyrönen TH, Tapaninen T, Neuvonen PJ, Niemi M, Backman JT. Tornio A, et al. Among authors: neuvonen pj, neuvonen m. Clin Pharmacol Ther. 2014 Oct;96(4):498-507. doi: 10.1038/clpt.2014.141. Epub 2014 Jun 27. Clin Pharmacol Ther. 2014. PMID: 24971633 Clinical Trial.
Gemfibrozil greatly increases plasma concentrations of cerivastatin.
Backman JT, Kyrklund C, Neuvonen M, Neuvonen PJ. Backman JT, et al. Among authors: neuvonen pj, neuvonen m. Clin Pharmacol Ther. 2002 Dec;72(6):685-91. doi: 10.1067/mcp.2002.128469. Clin Pharmacol Ther. 2002. PMID: 12496749 Clinical Trial.
134 results