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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1986 1
1987 1
1988 3
1989 2
1990 1
1991 4
1992 5
1993 3
1994 4
1995 3
1996 6
1997 5
1998 8
1999 4
2000 13
2001 10
2002 10
2003 12
2004 14
2005 18
2006 24
2007 21
2008 17
2009 28
2010 29
2011 36
2012 51
2013 52
2014 57
2015 64
2016 82
2017 69
2018 79
2019 98
2020 93
2021 117
2022 119
2023 46

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1,079 results

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Page 1
Alzheimer's disease.
Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM. Scheltens P, et al. Lancet. 2016 Jul 30;388(10043):505-17. doi: 10.1016/S0140-6736(15)01124-1. Epub 2016 Feb 24. Lancet. 2016. PMID: 26921134 Free article. Review.
Preclinical Alzheimer's disease is defined as biomarker evidence of Alzheimer's pathological changes in cognitively healthy individuals. Patients with subjective cognitive decline have been identified as a useful population in whom to look for p …
Preclinical Alzheimer's disease is defined as biomarker evidence of Alzheimer's pathological changes in c …
Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery.
Bai B, Vanderwall D, Li Y, Wang X, Poudel S, Wang H, Dey KK, Chen PC, Yang K, Peng J. Bai B, et al. Mol Neurodegener. 2021 Aug 12;16(1):55. doi: 10.1186/s13024-021-00474-z. Mol Neurodegener. 2021. PMID: 34384464 Free PMC article. Review.
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the advances and limitations in historic and recent AD proteomic research. ...In particular, …
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer …
TREM2, microglia, and Alzheimer's disease.
Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y. Qin Q, et al. Mech Ageing Dev. 2021 Apr;195:111438. doi: 10.1016/j.mad.2021.111438. Epub 2021 Jan 28. Mech Ageing Dev. 2021. PMID: 33516818 Review.
Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide association studies (GWAS). ...We conclude that TREM2 can not only influence microglial fun …
Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease …
Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities.
Reitz C. Reitz C. Expert Rev Mol Diagn. 2015 Mar;15(3):339-48. doi: 10.1586/14737159.2015.1002469. Epub 2015 Jan 29. Expert Rev Mol Diagn. 2015. PMID: 25634383 Free PMC article. Review.
Alzheimer's disease (AD), the most common form of dementia in western societies, is a pathologically and clinically heterogeneous disease with a strong genetic component. ...During the last 5 years, genome-wide association and whole-exome- and w …
Alzheimer's disease (AD), the most common form of dementia in western societies, is a pathologically and clinically het …
Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets.
Sierksma A, Escott-Price V, De Strooper B. Sierksma A, et al. Science. 2020 Oct 2;370(6512):61-66. doi: 10.1126/science.abb8575. Science. 2020. PMID: 33004512 Review.
To provide better prevention and treatment, we need to understand the environmental and genetic risks of Alzheimer's disease (AD). However, the definition of AD has been confounded with dementia in many studies. ...The lack of mechanistic understanding …
To provide better prevention and treatment, we need to understand the environmental and genetic risks of Alzheimer's …
Modeling Alzheimer's disease with iPSC-derived brain cells.
Penney J, Ralvenius WT, Tsai LH. Penney J, et al. Mol Psychiatry. 2020 Jan;25(1):148-167. doi: 10.1038/s41380-019-0468-3. Epub 2019 Aug 7. Mol Psychiatry. 2020. PMID: 31391546 Free PMC article. Review.
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed to benefit human patients. While hope remains that earlier …
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless promising therapeutics have sho …
TREM2, Microglia, and Neurodegenerative Diseases.
Yeh FL, Hansen DV, Sheng M. Yeh FL, et al. Trends Mol Med. 2017 Jun;23(6):512-533. doi: 10.1016/j.molmed.2017.03.008. Epub 2017 Apr 22. Trends Mol Med. 2017. PMID: 28442216 Review.
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent studies have advanced our understanding of TREM2 biology and microglial activities in aging and neurodegenerative brains, providing new …
Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. ...Recent st …
The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications.
Arranz AM, De Strooper B. Arranz AM, et al. Lancet Neurol. 2019 Apr;18(4):406-414. doi: 10.1016/S1474-4422(18)30490-3. Epub 2019 Feb 19. Lancet Neurol. 2019. PMID: 30795987 Review.
Although astrocytes have been known to display morphological alterations in Alzheimer's disease for more than a century, research has remained neurocentric. ...Thus, functional work studying human astrocytes generated from stem cells and exposed to pathologic …
Although astrocytes have been known to display morphological alterations in Alzheimer's disease for more than a century …
New insights on the role of microglia in synaptic pruning in health and disease.
Hong S, Dissing-Olesen L, Stevens B. Hong S, et al. Curr Opin Neurobiol. 2016 Feb;36:128-34. doi: 10.1016/j.conb.2015.12.004. Epub 2015 Dec 30. Curr Opin Neurobiol. 2016. PMID: 26745839 Free PMC article. Review.
Recent genome-wide association studies implicate microglia in Alzheimer's disease (AD) pathogenesis; however, their biological significance remains poorly understood. ...Emerging research on microglia function in the healthy brain is providing new i …
Recent genome-wide association studies implicate microglia in Alzheimer's disease (AD) pathogenesis; however, their bio …
Insights into Alzheimer's disease from single-cell genomic approaches.
Murdock MH, Tsai LH. Murdock MH, et al. Nat Neurosci. 2023 Feb;26(2):181-195. doi: 10.1038/s41593-022-01222-2. Epub 2023 Jan 2. Nat Neurosci. 2023. PMID: 36593328 Review.
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling has shown that Alzheimer's dementia involves the com …
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques a …
1,079 results