New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections.
Chem Asian J. 2019.
PMID: 31389664
Free PMC article.
Review.
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New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections.
Chem Asian J. 2019 Nov 18;14(22):3962-3968. doi: 10.1002/asia.201900841. Epub 2019 Aug 7.
Chem Asian J. 2019.
PMID: 31389664
Free PMC article.
Review.
Eight different compounds, all nucleoside analogues, could presently be considered as potential drug candidates for the treatment of Ebola virus (EBOV) and/or other hemorrhagic fever virus (HFV) infections. ...Four out of th …
Eight different compounds, all nucleoside analogues, could presently be considered as potential drug candidates for the tre …
Hantavirus pulmonary syndrome.
Virus Res. 2011 Dec;162(1-2):138-47. doi: 10.1016/j.virusres.2011.09.017. Epub 2011 Sep 17.
Virus Res. 2011.
PMID: 21945215
Review.
Hantaviruses have a worldwide distribution and are broadly split into the New World hantaviruses, which includes those causing HPS, and the Old World hantaviruses [including the prototype Hantaan virus (HTNV)], which are associated with a different disease, hemor …
Hantaviruses have a worldwide distribution and are broadly split into the New World hantaviruses, which includes those causing HPS, a …
New opportunities for field research on the pathogenesis and treatment of Lassa fever.
Antiviral Res. 2008 Apr;78(1):103-15. doi: 10.1016/j.antiviral.2007.11.003. Epub 2007 Dec 17.
Antiviral Res. 2008.
PMID: 18241935
Review.
Unlike many viral hemorrhagic fevers (VHFs), Lassa fever (LF) is not a rare disease that emerges only as sporadic cases or in outbreak form. ...Although civil unrest in this region over the past two decades has impeded capacity building and research, …
Unlike many viral hemorrhagic fevers (VHFs), Lassa fever (LF) is not a rare disease that emerges only as sporadi …
Lassa fever vaccine.
Expert Rev Vaccines. 2004 Apr;3(2):189-97. doi: 10.1586/14760584.3.2.189.
Expert Rev Vaccines. 2004.
PMID: 15056044
Review.
Lassa fever remains a serious challenge to public health in West Africa threatening both local residents in rural areas and those who serve them, particularly medical care providers. ...Lassa vaccine initiatives have suffered from a lack of funding in the past but bioterro …
Lassa fever remains a serious challenge to public health in West Africa threatening both local residents in rural areas and those who …
Development of Reverse Genetics for the Prototype New World Mammarenavirus Tacaribe Virus.
J Virol. 2020 Sep 15;94(19):e01014-20. doi: 10.1128/JVI.01014-20. Print 2020 Sep 15.
J Virol. 2020.
PMID: 32669332
Free PMC article.
TCRV has not been linked to human disease, but it has been shown to protect against Argentine hemorrhagic fever-like disease in marmosets infected with the New World mammarenavirus Junin virus (JUNV), indicating the potential of TCRV as a live-attenuat …
TCRV has not been linked to human disease, but it has been shown to protect against Argentine hemorrhagic fever-like disease i …
Broad-Spectrum Antiviral Strategies and Nucleoside Analogues.
Viruses. 2021 Apr 13;13(4):667. doi: 10.3390/v13040667.
Viruses. 2021.
PMID: 33924302
Free PMC article.
Review.
So far, broad-spectrum antivirals include two main categories: the family of drugs targeting the host-cell machinery essential for virus infection and replication, and the family of drugs directly targeting viruses. Among the molecules directly targeting viruses, nucleo …
So far, broad-spectrum antivirals include two main categories: the family of drugs targeting the host-cell machinery essential for virus …
New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase.
Antiviral Res. 2016 Oct;134:63-76. doi: 10.1016/j.antiviral.2016.08.006. Epub 2016 Aug 27.
Antiviral Res. 2016.
PMID: 27575793
Free article.
Review.
Worldwide, respiratory syncytial virus (RSV) causes severe disease in infants, the elderly, and immunocompromised people. ...In this article, we first provide an overview of the role of the RSV polymerase in viral mRNA transcription and genome replication. We then r …
Worldwide, respiratory syncytial virus (RSV) causes severe disease in infants, the elderly, and immunocompromised people. ...In this …
Treatment of Argentine hemorrhagic fever.
Antiviral Res. 2008 Apr;78(1):132-9. doi: 10.1016/j.antiviral.2007.10.010. Epub 2007 Nov 20.
Antiviral Res. 2008.
PMID: 18054395
Free PMC article.
Review.
Argentine hemorrhagic fever (AHF) is a rodent-borne illness caused by the arenavirus Junin that is endemic to the humid pampas of Argentina. ...However, alternative forms of treatment are called for due to current difficulties in early detection of AHF, relat …
Argentine hemorrhagic fever (AHF) is a rodent-borne illness caused by the arenavirus Junin that is endemic to the humid pampas …
Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries.
Curr Opin Virol. 2012 Apr;2(2):215-20. doi: 10.1016/j.coviro.2012.03.001.
Curr Opin Virol. 2012.
PMID: 22482717
Review.
Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral infection described in Asia, Africa and Europe. ...The clinical features show common dramatic progress characterized by hemorrhage, myalgia, and fever. Besides the direct infection of endothelium, …
Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral infection described in Asia, Africa and Europe. ...The clinical …
A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'-C-Methylguanosine for the Treatment of Dengue Virus Infection.
Antimicrob Agents Chemother. 2020 Nov 17;64(12):e00654-20. doi: 10.1128/AAC.00654-20. Print 2020 Nov 17.
Antimicrob Agents Chemother. 2020.
PMID: 32958712
Free PMC article.
We identified a cyclic phosphoramidate, prodrug 17, demonstrating well-balanced anti-dengue virus cellular activity and in vitro stability profiles. We further determined the PBMC concentration of active triphosphate needed to inhibit virus replication by 50% (TP(50 …
We identified a cyclic phosphoramidate, prodrug 17, demonstrating well-balanced anti-dengue virus cellular activity and in vitro stab …
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