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64 results

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Page 1
New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections.
De Clercq E. De Clercq E. Chem Asian J. 2019 Nov 18;14(22):3962-3968. doi: 10.1002/asia.201900841. Epub 2019 Aug 7. Chem Asian J. 2019. PMID: 31389664 Free PMC article. Review.
Eight different compounds, all nucleoside analogues, could presently be considered as potential drug candidates for the treatment of Ebola virus (EBOV) and/or other hemorrhagic fever virus (HFV) infections. ...Four out of th …
Eight different compounds, all nucleoside analogues, could presently be considered as potential drug candidates for the tre …
Hantavirus pulmonary syndrome.
Macneil A, Nichol ST, Spiropoulou CF. Macneil A, et al. Virus Res. 2011 Dec;162(1-2):138-47. doi: 10.1016/j.virusres.2011.09.017. Epub 2011 Sep 17. Virus Res. 2011. PMID: 21945215 Review.
Hantaviruses have a worldwide distribution and are broadly split into the New World hantaviruses, which includes those causing HPS, and the Old World hantaviruses [including the prototype Hantaan virus (HTNV)], which are associated with a different disease, hemor …
Hantaviruses have a worldwide distribution and are broadly split into the New World hantaviruses, which includes those causing HPS, a …
New opportunities for field research on the pathogenesis and treatment of Lassa fever.
Khan SH, Goba A, Chu M, Roth C, Healing T, Marx A, Fair J, Guttieri MC, Ferro P, Imes T, Monagin C, Garry RF, Bausch DG; Mano River Union Lassa Fever Network. Khan SH, et al. Antiviral Res. 2008 Apr;78(1):103-15. doi: 10.1016/j.antiviral.2007.11.003. Epub 2007 Dec 17. Antiviral Res. 2008. PMID: 18241935 Review.
Unlike many viral hemorrhagic fevers (VHFs), Lassa fever (LF) is not a rare disease that emerges only as sporadic cases or in outbreak form. ...Although civil unrest in this region over the past two decades has impeded capacity building and research, …
Unlike many viral hemorrhagic fevers (VHFs), Lassa fever (LF) is not a rare disease that emerges only as sporadi …
Development of Reverse Genetics for the Prototype New World Mammarenavirus Tacaribe Virus.
Ye C, de la Torre JC, Martínez-Sobrido L. Ye C, et al. J Virol. 2020 Sep 15;94(19):e01014-20. doi: 10.1128/JVI.01014-20. Print 2020 Sep 15. J Virol. 2020. PMID: 32669332 Free PMC article.
TCRV has not been linked to human disease, but it has been shown to protect against Argentine hemorrhagic fever-like disease in marmosets infected with the New World mammarenavirus Junin virus (JUNV), indicating the potential of TCRV as a live-attenuat …
TCRV has not been linked to human disease, but it has been shown to protect against Argentine hemorrhagic fever-like disease i …
Treatment of Argentine hemorrhagic fever.
Enria DA, Briggiler AM, Sánchez Z. Enria DA, et al. Antiviral Res. 2008 Apr;78(1):132-9. doi: 10.1016/j.antiviral.2007.10.010. Epub 2007 Nov 20. Antiviral Res. 2008. PMID: 18054395 Free PMC article. Review.
Argentine hemorrhagic fever (AHF) is a rodent-borne illness caused by the arenavirus Junin that is endemic to the humid pampas of Argentina. ...However, alternative forms of treatment are called for due to current difficulties in early detection of AHF, relat …
Argentine hemorrhagic fever (AHF) is a rodent-borne illness caused by the arenavirus Junin that is endemic to the humid pampas …
Treatment and management of Crimean-Congo hemorrhagic fever.
Bulut R, Kandemir B, Erayman İ, Keskin PB, Kurt EK. Bulut R, et al. J Vector Borne Dis. 2026 Jan 1;63(1):67-73. doi: 10.4103/jvbd.jvbd_18_25. Epub 2026 Feb 27. J Vector Borne Dis. 2026. PMID: 40485565 Free article.
BACKGROUND OBJECTIVES: Crimean-Congo hemorrhagic fever (CCHF) is a tick-bome viral infection with a wide geographic distribution globally. The clinical severity of CCHF varies, with reported mortality rates reaching up to 60%. Despite its spread to new …
BACKGROUND OBJECTIVES: Crimean-Congo hemorrhagic fever (CCHF) is a tick-bome viral infection with a wide geographic dis …
Broad-Spectrum Antiviral Strategies and Nucleoside Analogues.
Geraghty RJ, Aliota MT, Bonnac LF. Geraghty RJ, et al. Viruses. 2021 Apr 13;13(4):667. doi: 10.3390/v13040667. Viruses. 2021. PMID: 33924302 Free PMC article. Review.
So far, broad-spectrum antivirals include two main categories: the family of drugs targeting the host-cell machinery essential for virus infection and replication, and the family of drugs directly targeting viruses. Among the molecules directly targeting viruses, nucleo …
So far, broad-spectrum antivirals include two main categories: the family of drugs targeting the host-cell machinery essential for virus …
Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease.
Welch SR, Spengler JR, Westover JB, Bailey KW, Davies KA, Aida-Ficken V, Bluemling GR, Boardman KM, Wasson SR, Mao S, Kuiper DL, Hager MW, Saindane MT, Andrews MK, Krueger RE, Sticher ZM, Jung KH, Chatterjee P, Shrivastava-Ranjan P, Lo MK, Coleman-McCray JD, Sorvillo TE, Genzer SC, Scholte FEM, Kelly JA, Jenks MH, McMullan LK, Albariño CG, Montgomery JM, Painter GR, Natchus MG, Kolykhalov AA, Gowen BB, Spiropoulou CF, Flint M. Welch SR, et al. Sci Transl Med. 2024 Nov 20;16(774):eado7034. doi: 10.1126/scitranslmed.ado7034. Epub 2024 Nov 20. Sci Transl Med. 2024. PMID: 39565871 Free PMC article.
Here, we show that 4'-fluorouridine (4'-FlU; EIDD-2749), an orally available ribonucleoside analog, has antiviral activity against multiple hemorrhagic fever viruses in cell culture, including Nipah virus, Crimean-Congo hemorrhagic fever viru …
Here, we show that 4'-fluorouridine (4'-FlU; EIDD-2749), an orally available ribonucleoside analog, has antiviral activity against multiple …
Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries.
Ergonul O. Ergonul O. Curr Opin Virol. 2012 Apr;2(2):215-20. doi: 10.1016/j.coviro.2012.03.001. Curr Opin Virol. 2012. PMID: 22482717 Review.
Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral infection described in Asia, Africa and Europe. ...The clinical features show common dramatic progress characterized by hemorrhage, myalgia, and fever. Besides the direct infection of endothelium, …
Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral infection described in Asia, Africa and Europe. ...The clinical …
Arenaviruses other than Lassa virus.
Charrel RN, de Lamballerie X. Charrel RN, et al. Antiviral Res. 2003 Jan;57(1-2):89-100. doi: 10.1016/s0166-3542(02)00202-4. Antiviral Res. 2003. PMID: 12615305 Review.
The family Arenaviridae includes 23 viral species, of which 5 can cause viral hemorrhagic fevers with a case fatality rate of about 20%. These five viruses are Junin, Machupo, Guanarito, Sabia and Lassa virus, the manipulation of which requires …
The family Arenaviridae includes 23 viral species, of which 5 can cause viral hemorrhagic fevers with a case fat …
64 results