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Blessings in disguise: biological benefits of prion-like mechanisms.
Newby GA, Lindquist S. Newby GA, et al. Trends Cell Biol. 2013 Jun;23(6):251-9. doi: 10.1016/j.tcb.2013.01.007. Epub 2013 Feb 26. Trends Cell Biol. 2013. PMID: 23485338
Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism.
Jarosz DF, Brown JCS, Walker GA, Datta MS, Ung WL, Lancaster AK, Rotem A, Chang A, Newby GA, Weitz DA, Bisson LF, Lindquist S. Jarosz DF, et al. Cell. 2014 Aug 28;158(5):1083-1093. doi: 10.1016/j.cell.2014.07.025. Cell. 2014. PMID: 25171409 Free PMC article.
Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools.
Schütz M, Batyuk A, Klenk C, Kummer L, de Picciotto S, Gülbakan B, Wu Y, Newby GA, Zosel F, Schöppe J, Sedlák E, Mittl PRE, Zenobi R, Wittrup KD, Plückthun A. Schütz M, et al. J Mol Biol. 2016 Mar 27;428(6):1272-1289. doi: 10.1016/j.jmb.2016.01.017. Epub 2016 Jan 23. J Mol Biol. 2016. PMID: 26812208
Luminidependens (LD) is an Arabidopsis protein with prion behavior.
Chakrabortee S, Kayatekin C, Newby GA, Mendillo ML, Lancaster A, Lindquist S. Chakrabortee S, et al. Proc Natl Acad Sci U S A. 2016 May 24;113(21):6065-70. doi: 10.1073/pnas.1604478113. Epub 2016 Apr 25. Proc Natl Acad Sci U S A. 2016. PMID: 27114519 Free PMC article.
A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance.
Newby GA, Kiriakov S, Hallacli E, Kayatekin C, Tsvetkov P, Mancuso CP, Bonner JM, Hesse WR, Chakrabortee S, Manogaran AL, Liebman SW, Lindquist S, Khalil AS. Newby GA, et al. Cell. 2017 Nov 2;171(4):966-979.e18. doi: 10.1016/j.cell.2017.09.041. Epub 2017 Oct 19. Cell. 2017. PMID: 29056345 Free PMC article.
Microbial specialization by prions.
Newby GA, Kayatekin C. Newby GA, et al. Prion. 2018 Jul 24;12(3-4):1-5. doi: 10.1080/19336896.2018.1469945. Online ahead of print. Prion. 2018. PMID: 29923447 Free PMC article.
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Fanning S, et al. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. Mol Cell. 2019. PMID: 30527540 Free PMC article.
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction.
Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR. Koblan LW, et al. Nat Biotechnol. 2018 Oct;36(9):843-846. doi: 10.1038/nbt.4172. Epub 2018 May 29. Nat Biotechnol. 2018. PMID: 29813047 Free PMC article.
Base Editing: Efficient Installation of Point Mutations with Minimal Byproducts.
Newby GA. Newby GA. Stem Cells Dev. 2019 Jun 1;28(11):712-713. doi: 10.1089/scd.2019.0080. Epub 2019 May 20. Stem Cells Dev. 2019. PMID: 31107171 No abstract available.
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