Newby Z - Search Results

1

The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.

Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. Newby Z, et al. Biochemistry. 2006 Jun 20;45(24):7415-28. doi: 10.1021/bi060152s. Biochemistry. 2006. PMID: 16768437 Free PMC article.

2

Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.

Newby ZE, O'Connell J 3rd, Robles-Colmenares Y, Khademi S, Miercke LJ, Stroud RM. Newby ZE, et al. Nat Struct Mol Biol. 2008 Jun;15(6):619-25. doi: 10.1038/nsmb.1431. Epub 2008 May 25. Nat Struct Mol Biol. 2008. PMID: 18500352 Free PMC article.

3

A general protocol for the crystallization of membrane proteins for X-ray structural investigation.

Newby ZE, O'Connell JD 3rd, Gruswitz F, Hays FA, Harries WE, Harwood IM, Ho JD, Lee JK, Savage DF, Miercke LJ, Stroud RM. Newby ZE, et al. Nat Protoc. 2009;4(5):619-37. doi: 10.1038/nprot.2009.27. Nat Protoc. 2009. PMID: 19360018 Free PMC article.

4

Cell-free complements in vivo expression of the E. coli membrane proteome.

Savage DF, Anderson CL, Robles-Colmenares Y, Newby ZE, Stroud RM. Savage DF, et al. Among authors: newby ze. Protein Sci. 2007 May;16(5):966-76. doi: 10.1110/ps.062696307. Protein Sci. 2007. PMID: 17456747 Free PMC article.

5

Transition state stabilization by general acid catalysis, water expulsion, and enzyme reorganization in Medicago savita chalcone isomerase.

Hur S, Newby ZE, Bruice TC. Hur S, et al. Among authors: newby ze. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2730-5. doi: 10.1073/pnas.0308264100. Epub 2004 Feb 20. Proc Natl Acad Sci U S A. 2004. PMID: 14978275 Free PMC article.

6

A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N6)-methyltransferase from Thermus aquaticus.

Newby ZE, Lau EY, Bruice TC. Newby ZE, et al. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7922-7. doi: 10.1073/pnas.122231499. Proc Natl Acad Sci U S A. 2002. PMID: 12060740 Free PMC article.

7

A theoretical examination of the acid-catalyzed and noncatalyzed ring-opening reaction of an oxirane by nucleophilic addition of acetate. Implications to epoxide hydrolases.

Lau EY, Newby ZE, Bruice TC. Lau EY, et al. Among authors: newby ze. J Am Chem Soc. 2001 Apr 11;123(14):3350-7. doi: 10.1021/ja0037724. J Am Chem Soc. 2001. PMID: 11457071

8

Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.

Farand J, Mai N, Chandrasekhar J, Newby ZE, Van Veldhuizen J, Loyer-Drew J, Venkataramani C, Guerrero J, Kwok A, Li N, Zherebina Y, Wilbert S, Zablocki J, Phillips G, Watkins WJ, Mourey R, Notte GT. Farand J, et al. Among authors: newby ze. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5926-5930. doi: 10.1016/j.bmcl.2016.10.092. Epub 2016 Nov 2. Bioorg Med Chem Lett. 2016. PMID: 27876318

9

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

Sperandio D, Aktoudianakis V, Babaoglu K, Chen X, Elbel K, Chin G, Corkey B, Du J, Jiang B, Kobayashi T, Mackman R, Martinez R, Yang H, Zablocki J, Kusam S, Jordan K, Webb H, Bates JG, Lad L, Mish M, Niedziela-Majka A, Metobo S, Sapre A, Hung M, Jin D, Fung W, Kan E, Eisenberg G, Larson N, Newby ZER, Lansdon E, Tay C, Neve RM, Shevick SL, Breckenridge DG. Sperandio D, et al. Among authors: newby zer. Bioorg Med Chem. 2019 Feb 1;27(3):457-469. doi: 10.1016/j.bmc.2018.11.020. Epub 2018 Nov 15. Bioorg Med Chem. 2019. PMID: 30606676

10

Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.

Farand J, Kropf JE, Blomgren P, Xu J, Schmitt AC, Newby ZE, Wang T, Murakami E, Barauskas O, Sudhamsu J, Feng JY, Niedziela-Majka A, Schultz BE, Schwartz K, Viatchenko-Karpinski S, Kornyeyev D, Kashishian A, Fan P, Chen X, Lansdon EB, Ports MO, Currie KS, Watkins WJ, Notte GT. Farand J, et al. Among authors: newby ze. ACS Med Chem Lett. 2019 Nov 19;11(3):358-364. doi: 10.1021/acsmedchemlett.9b00420. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184970 Free PMC article.

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