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How to develop a successful cancer drug--molecules to medicines or targets to treatments?
Newell DR. Newell DR. Eur J Cancer. 2005 Mar;41(5):676-82. doi: 10.1016/j.ejca.2004.12.024. Eur J Cancer. 2005. PMID: 15763642 Review.
The EORTC Laboratory Research Division. European Organisation for Research and Treatment of Cancer.
BrĂ¼nner N, Double J, Fichtner I, Gescher A, Newell D, Oosterhuis W, Price P. BrĂ¼nner N, et al. Among authors: newell d. Eur J Cancer. 2002 Mar;38 Suppl 4:S14-8. doi: 10.1016/s0959-8049(01)00455-5. Eur J Cancer. 2002. PMID: 11858958
The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition.
Haagensen EJ, Kyle S, Beale GS, Maxwell RJ, Newell DR. Haagensen EJ, et al. Among authors: newell dr. Br J Cancer. 2012 Apr 10;106(8):1386-94. doi: 10.1038/bjc.2012.70. Epub 2012 Mar 13. Br J Cancer. 2012. PMID: 22415236 Free PMC article.
Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells.
Johnson N, Bentley J, Wang LZ, Newell DR, Robson CN, Shapiro GI, Curtin NJ. Johnson N, et al. Among authors: newell dr. Br J Cancer. 2010 Jan 19;102(2):342-50. doi: 10.1038/sj.bjc.6605479. Epub 2009 Dec 15. Br J Cancer. 2010. PMID: 20010939 Free PMC article.
Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.
Newell DR, Searle KM, Westwood NB, Burtles SS; Cancer Research UK Phase I/II Clinical Trials Committee. Newell DR, et al. Br J Cancer. 2003 Aug 4;89(3):437-54. doi: 10.1038/sj.bjc.6601106. Br J Cancer. 2003. PMID: 12888809 Free PMC article. No abstract available.
Decreased telomerase activity is not a reliable indicator of chemosensitivity in testicular cancer cell lines.
Cressey TR, Tilby MJ, Newell DR. Cressey TR, et al. Among authors: newell dr. Eur J Cancer. 2002 Mar;38(4):586-93. doi: 10.1016/s0959-8049(01)00406-3. Eur J Cancer. 2002. PMID: 11872354
The impact of p53 status on cellular sensitivity to antifolate drugs.
Lu X, Errington J, Curtin NJ, Lunec J, Newell DR. Lu X, et al. Among authors: newell dr. Clin Cancer Res. 2001 Jul;7(7):2114-23. Clin Cancer Res. 2001. PMID: 11448931
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro.
Bowman KJ, Newell DR, Calvert AH, Curtin NJ. Bowman KJ, et al. Among authors: newell dr. Br J Cancer. 2001 Jan 5;84(1):106-12. doi: 10.1054/bjoc.2000.1555. Br J Cancer. 2001. PMID: 11139322 Free PMC article.
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.
Delaney CA, Wang LZ, Kyle S, White AW, Calvert AH, Curtin NJ, Durkacz BW, Hostomsky Z, Newell DR. Delaney CA, et al. Among authors: newell dr. Clin Cancer Res. 2000 Jul;6(7):2860-7. Clin Cancer Res. 2000. PMID: 10914735
Cellular glutathione as a determinant of the sensitivity of colorectal tumour cell-lines to ZD2767 antibody-directed enzyme prodrug therapy (ADEPT).
Monks NR, Calvete JA, Curtin NJ, Blakey DC, East SJ, Newell DR. Monks NR, et al. Among authors: newell dr. Br J Cancer. 2000 Jul;83(2):267-9. doi: 10.1054/bjoc.2000.1240. Br J Cancer. 2000. PMID: 10901381 Free PMC article.
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