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Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.
Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP. Grasfeder LL, et al. Mol Endocrinol. 2009 Aug;23(8):1171-82. doi: 10.1210/me.2009-0024. Epub 2009 Apr 23. Mol Endocrinol. 2009. PMID: 19389810 Free PMC article.
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.
Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Dong B, et al. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6. doi: 10.1073/pnas.0909731106. Epub 2009 Oct 22. Proc Natl Acad Sci U S A. 2009. PMID: 19850873 Free PMC article.
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Yoon JC, et al. Dev Cell. 2003 Jul;5(1):73-83. doi: 10.1016/s1534-5807(03)00170-9. Dev Cell. 2003. PMID: 12852853
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Yoon JC, et al. Nature. 2001 Sep 13;413(6852):131-8. doi: 10.1038/35093050. Nature. 2001. PMID: 11557972
Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.
Shang J, Li J, Keller MP, Hohmeier HE, Wang Y, Feng Y, Zhou HH, Shen X, Rabaglia M, Soni M, Attie AD, Newgard CB, Thornberry NA, Howard AD, Zhou YP. Shang J, et al. Mol Endocrinol. 2015 Sep;29(9):1243-53. doi: 10.1210/me.2014-1335. Epub 2015 Jul 28. Mol Endocrinol. 2015. PMID: 26218441 Free PMC article.
Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.
Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH. Malakauskas SM, et al. Mol Endocrinol. 2009 Jun;23(6):881-92. doi: 10.1210/me.2008-0274. Epub 2009 Feb 26. Mol Endocrinol. 2009. PMID: 19246514 Free PMC article.
Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.
Hayes HL, Moss LG, Schisler JC, Haldeman JM, Zhang Z, Rosenberg PB, Newgard CB, Hohmeier HE. Hayes HL, et al. Mol Cell Biol. 2013 Oct;33(20):4017-29. doi: 10.1128/MCB.00469-13. Epub 2013 Aug 12. Mol Cell Biol. 2013. PMID: 23938296 Free PMC article.
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