Therapy for nerve agent poisoning

Arch Neurol. 2004 May;61(5):649-52. doi: 10.1001/archneur.61.5.649.

Abstract

Neurologists need to familiarize themselves with nerve agents, the most toxic of the chemical warfare agents. Their mode of action lies within the nervous system, and nonneurologists will look to neurologists for expert advice on therapy. These agents cause rapid-onset cholinergic crisis amenable to prompt treatment with specific antidotes. Experience on the battlefield and in terrorist attacks demonstrates that therapy saves lives.

Publication types

  • Review

MeSH terms

  • Antidotes / therapeutic use*
  • Atropine / therapeutic use
  • Chemical Warfare Agents / chemistry
  • Chemical Warfare Agents / poisoning*
  • Humans
  • Neurotoxicity Syndromes / physiopathology
  • Neurotoxicity Syndromes / therapy*
  • Neurotoxins / chemistry
  • Neurotoxins / poisoning*
  • Organophosphate Poisoning
  • Organophosphates / chemistry
  • Organothiophosphorus Compounds / chemistry
  • Organothiophosphorus Compounds / poisoning
  • Pralidoxime Compounds / therapeutic use
  • Pyridostigmine Bromide / therapeutic use
  • Sarin / chemistry
  • Sarin / poisoning
  • Soman / chemistry
  • Soman / poisoning

Substances

  • Antidotes
  • Chemical Warfare Agents
  • Neurotoxins
  • Organophosphates
  • Organothiophosphorus Compounds
  • Pralidoxime Compounds
  • Atropine
  • Soman
  • VX
  • Sarin
  • Pyridostigmine Bromide
  • pralidoxime
  • tabun