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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M, Mihailov E, Liu C, Kraja AT, Fallgaard Nielsen S, Rasheed A, Samuel M, Zhao W, Bonnycastle LL, Jackson AU, Narisu N, Swift AJ, Southam L, Marten J, Huyghe JR, Stančáková A, Fava C, Ohlsson T, Matchan A, Stirrups KE, Bork-Jensen J, Gjesing AP, Kontto J, Perola M, Shaw-Hawkins S, Havulinna AS, Zhang H, Donnelly LA, Groves CJ, Rayner NW, Neville MJ, Robertson NR, Yiorkas AM, Herzig KH, Kajantie E, Zhang W, Willems SM, Lannfelt L, Malerba G, Soranzo N, Trabetti E, Verweij N, Evangelou E, Moayyeri A, Vergnaud AC, Nelson CP, Poveda A, Varga TV, Caslake M, de Craen AJ, Trompet S, Luan J, Scott RA, Harris SE, Liewald DC, Marioni R, Menni C, Farmaki AE, Hallmans G, Renström F, Huffman JE, Hassinen M, Burgess S, Vasan RS, Felix JF; CHARGE-Heart Failure Consortium; Uria-Nickelsen M, Malarstig A, Reily DF, Hoek M, Vogt T, Lin H, Lieb W; EchoGen Consortium; Traylor M, Markus HF; METASTROKE Consortium; Highland HM, Justice AE, Marouli E; GIANT Consortium; Lindström J, U… See abstract for full author list ➔ Surendran P, et al. Nat Genet. 2016 Oct;48(10):1151-1161. doi: 10.1038/ng.3654. Epub 2016 Sep 12. Nat Genet. 2016. PMID: 27618447 Free PMC article.
On the significance of linkage studies of complex traits.
Newton-Cheh C, Larson M, Kathiresan S, O'Donnell C. Newton-Cheh C, et al. Am J Hum Genet. 2004 Jul;75(1):151-2; author reply 152-4. doi: 10.1086/422220. Am J Hum Genet. 2004. PMID: 15164311 Free PMC article. No abstract available.
On the interpretation of genetic association studies.
Kathiresan S, Newton-Cheh C, Gerszten RE. Kathiresan S, et al. Eur Heart J. 2004 Aug;25(16):1378-81. doi: 10.1016/j.ehj.2004.06.035. Eur Heart J. 2004. PMID: 15321696 No abstract available.
Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community.
Kathiresan S, Larson MG, Vasan RS, Guo CY, Vita JA, Mitchell GF, Keyes MJ, Newton-Cheh C, Musone SL, Lochner AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Kathiresan S, et al. Circulation. 2005 Sep 6;112(10):1419-27. doi: 10.1161/CIRCULATIONAHA.105.544619. Epub 2005 Aug 29. Circulation. 2005. PMID: 16129794
Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.
Kathiresan S, Larson MG, Vasan RS, Guo CY, Gona P, Keaney JF Jr, Wilson PW, Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Kathiresan S, et al. Circulation. 2006 Mar 21;113(11):1415-23. doi: 10.1161/CIRCULATIONAHA.105.591271. Epub 2006 Mar 13. Circulation. 2006. PMID: 16534007
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson MG, Wichmann HE, Marbán E, O'Donnell CJ, Hirschhorn JN, Kääb S, Spooner PM, Meitinger T, Chakravarti A. Arking DE, et al. Nat Genet. 2006 Jun;38(6):644-51. doi: 10.1038/ng1790. Epub 2006 Apr 30. Nat Genet. 2006. PMID: 16648850
Multiple biomarkers and the risk of incident hypertension.
Wang TJ, Gona P, Larson MG, Levy D, Benjamin EJ, Tofler GH, Jacques PF, Meigs JB, Rifai N, Selhub J, Robins SJ, Newton-Cheh C, Vasan RS. Wang TJ, et al. Hypertension. 2007 Mar;49(3):432-8. doi: 10.1161/01.HYP.0000256956.61872.aa. Epub 2007 Jan 22. Hypertension. 2007. PMID: 17242302
256 results