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Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using biofilter, and gene-environment interactions using the Phenx Toolkit*.
Pendergrass SA, Verma SS, Hall MA, Holzinger ER, Moore CB, Wallace JR, Dudek SM, Huggins W, Kitchner T, Waudby C, Berg R, Mccarty CA, Ritchie MD. Pendergrass SA, et al. Pac Symp Biocomput. 2015:495-505. Pac Symp Biocomput. 2015. PMID: 25741542
We also conducted gene-environment interaction analyses for all GWAS SNPs and a set of environmental factors from the PhenX Toolkit: smoking, UV exposure, and alcohol use;these environmental factors have been previously associated with the forma …
We also conducted gene-environment interaction analyses for all GWAS SNPs and a set of environmental factors from the …
Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using Biofilter, and gene-environment interactions using the PhenX Toolkit.
Pendergrass SA, Verma SS, Holzinger ER, Moore CB, Wallace J, Dudek SM, Huggins W, Kitchner T, Waudby C, Berg R, McCarty CA, Ritchie MD. Pendergrass SA, et al. Pac Symp Biocomput. 2013:147-58. Pac Symp Biocomput. 2013. PMID: 23424120 Free PMC article. Corrected and republished.
To build our SNP-SNP interaction models we utilized a prior-knowledge driven filtering method called Biofilter to minimize the multiple testing burden of exploring the vast array of interaction models possible from our extensive number of SNPs. …
To build our SNP-SNP interaction models we utilized a prior-knowledge driven filtering method called Biofilter t …